| Host: |
Rabbit |
| Applications: |
IHC/WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-AMPA2 is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Lyophilised |
| Purification: |
IgG purified |
| Dilution Range: |
IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Storage Instruction: |
Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: |
GRIA2 |
| Gene ID: |
2891 |
| Uniprot ID: |
GRIA2_HUMAN |
| Specificity: |
Specific for AMPA2. |
| Immunogen: |
A synthetic peptide from human AMPA2 conjugated to blue carrier protein was used as the antigen. |
| Function | Ionotropic glutamate receptor that functions as a ligand-gated cation channel, gated by L-glutamate and glutamatergic agonists such as alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA), quisqualic acid, and kainic acid. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system and plays an important role in fast excitatory synaptic transmission. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse upon entry of monovalent and divalent cations such as sodium and calcium. The receptor then desensitizes rapidly and enters in a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of L-glutamate. Through complex formation with NSG1, GRIP1 and STX12 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting. |
| Protein Name | Glutamate Receptor 2Glur-2Ampa-Selective Glutamate Receptor 2Glur-BGlur-K2Glutamate Receptor Ionotropic - Ampa 2 |
| Database Links | Reactome: R-HSA-399710Reactome: R-HSA-416993Reactome: R-HSA-438066Reactome: R-HSA-9022699Reactome: R-HSA-9620244 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinPostsynaptic Cell MembranePostsynaptic Density MembraneInteraction With Cacng2Cnih2 And Cnih3 Promotes Cell Surface ExpressionDisplays A Somatodendritic Localization And Is Excluded From Axons In Neurons |
| Alternative Antibody Names | Anti-Glutamate Receptor 2 antibodyAnti-Glur-2 antibodyAnti-Ampa-Selective Glutamate Receptor 2 antibodyAnti-Glur-B antibodyAnti-Glur-K2 antibodyAnti-Glutamate Receptor Ionotropic - Ampa 2 antibodyAnti-GRIA2 antibodyAnti-GluA2 antibodyAnti-GLUR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
