| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Angiomotin (710-790 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AMOT |
| Gene ID: |
154796 |
| Uniprot ID: |
AMOT_HUMAN |
| Immunogen Region: |
710-790 aa |
| Specificity: |
AMOT Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 710-790 |
| Post Translational Modifications | Polyubiquitinated by NEDD4, NEDD4L and ITCH, leading to proteasomal degradation. |
| Function | Plays a central role in tight junction maintenance via the complex formed with ARHGAP17, which acts by regulating the uptake of polarity proteins at tight junctions. Appears to regulate endothelial cell migration and tube formation. May also play a role in the assembly of endothelial cell-cell junctions. |
| Protein Name | Angiomotin |
| Database Links | Reactome: R-HSA-2028269 Q4VCS5-1Reactome: R-HSA-9762292 Q4VCS5-2 |
| Cellular Localisation | Cell JunctionTight JunctionLocalized On The Cell SurfaceMay Act As A Transmembrane Protein |
| Alternative Antibody Names | Anti-Angiomotin antibodyAnti-AMOT antibodyAnti-KIAA1071 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
