| Host: | Mouse |
| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-AMH (R26-R451) is suitable for use in ELISA research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 11303 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | 50 mM Na-citrate, pH 6.0, 0.9 % NaCI, 0.095 % NaN3 as a preservative |
| Purification: | Greater than 95% purity |
| Concentration: | 5.0 mg/ml (+/-10 %) |
| Storage Instruction: | 12 months from manufacturing at 2–8°C. Temperature analysis:-70 °C, 21 days Not Determined (N/D)-20 °C, 14 days OK +4 °C, 14 days OK +35 °C, 14 days OK +45 °C, 7 days OK. Shelf life stability testing at 2–8 °C in the product buffer. |
| Association Rate Constant: | 2.1 x 106 1/Ms |
| Determination Method: | SPR analysis (ProteOn XPR36) |
| Immunoreactivity: | 80–120 % compared to the reference sample in an FIA test |
| Gene Symbol: | AMH |
| Gene ID: | 268 |
| Uniprot ID: | MIS_HUMAN |
| Immunogen Region: | R26-R451 |
| Immunogen: | Human anti-Müllerian hormone (AMH) |
| Tissue Specificity | In ovaries, AMH is detected in granulosa cells of early growing follicles. |
| Post Translational Modifications | Preproprotein is proteolytically processed to generate N- and C-terminal cleavage products that homodimerize and associate to form a biologically active non-covalent complex. Binding of the non-covalent complex to AMHR2 induces dissociation of the pro-region from the mature C-terminal dimer. The N-terminal portion of the protein, despite having no intrinsic activity, has the role of amplifying the activity of the C-terminus. |
| Function | Plays an important role in several reproductive functions. Induces Muellerian duct regression during male fetal sexual differentiation. Also plays a role in Leydig cell differentiation and function. In female acts as a negative regulator of the primordial to primary follicle transition and decreases FSH sensitivity of growing follicles. AMH signals by binding to a specific type-II receptor, AMHR2, that heterodimerizes with type-I receptors (ACVR1 and BMPR1A), and recruiting SMAD proteins that are translocated to the nucleus to regulate target gene expression. |
| Protein Name | Muellerian-Inhibiting Factor Anti-Muellerian Hormone Amh Muellerian-Inhibiting Substance Mis |
| Database Links | Reactome: R-HSA-201451 Reactome: R-HSA-9690406 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Muellerian-Inhibiting Factor antibody Anti-Anti-Muellerian Hormone antibody Anti-Amh antibody Anti-Muellerian-Inhibiting Substance antibody Anti-Mis antibody Anti-AMH antibody Anti-MIF antibody |
Information sourced from Uniprot.org