alpha 1a Adrenergic Receptor antibody western blot rat brain C6 STJA0034006

Anti-alpha 1a Adrenergic Receptor antibody [R04-8B8] (STJA0034006)

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STJA0034006
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Short Description :Rabbit monoclonal anti-alpha 1a Adrenergic Receptor for use in WB and IHC-P in Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:WB/IHC-P
Host:Rabbit
Reactivity:Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Monoclonal
Clone ID :R04-8B8
Isotype:IgG
Conjugation:Unconjugated
Concentration:0.3 mg/mL
Purification:Affinity Purified
Dilution Range:WB 1:500-1:1000
IHC 1:50-1:100
Formulation:50mM Tris-Glycine (pH 7.4) , 0.15M NaCl, 40% Glycerol, 0.01% Sodium azide and 0.05% BSA
Storage Instruction:Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles.
Gene Symbol:ADRA1A
Gene ID:148
Uniprot ID:ADA1A_HUMAN
Immunogen:A synthetic peptide of human alpha 1a Adrenergic Receptor
Tissue Specificity Expressed in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. Within the prostate, expressed in the apex, base, periurethral and lateral lobe. Isoform 4 is the most abundant isoform expressed in the prostate with high levels also detected in liver and heart.
Post Translational Modifications C-terminal Ser or Thr residues may be phosphorylated.
Function This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Protein Name Alpha-1a Adrenergic Receptor
Alpha-1a Adrenoreceptor
Alpha-1a Adrenoceptor
Alpha-1c Adrenergic Receptor
Alpha-Adrenergic Receptor 1c
Database Links Reactome: R-HSA-390696
Reactome: R-HSA-416476
Reactome: R-HSA-416482
Cellular Localisation Nucleus Membrane
Multi-Pass Membrane Protein
Cell Membrane
Cytoplasm
Membrane
Caveola
Location At The Nuclear Membrane Facilitates Heterooligomerization And Regulates Erk-Mediated Signaling In Cardiac Myocytes
Colocalizes With Gnaq
Plcb1 As Well As Lap2 At The Nuclear Membrane Of Cardiac Myocytes
Alternative Antibody Names Anti-Alpha-1a Adrenergic Receptor antibody
Anti-Alpha-1a Adrenoreceptor antibody
Anti-Alpha-1a Adrenoceptor antibody
Anti-Alpha-1c Adrenergic Receptor antibody
Anti-Alpha-Adrenergic Receptor 1c antibody
Anti-ADRA1A antibody
Anti-ADRA1C antibody

Information sourced from Uniprot.org

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