Anti-Aldo-keto Reductase 1C1/AKR1C1 antibody (1-323aa) [AT6D10] (STJA0041604)

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STJA0041604
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Host: Mouse
Applications: ELISA/WB/ICC/IF/FACS
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Mouse monoclonal anti-Aldo-keto Reductase 1C1/AKR1C1 (1-323aa) for use in ELISA, WB, ICC, IF and FACS in Human samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Monoclonal
Clone ID : AT6D10
Conjugation: Unconjugated
Isotype: IgG1k
Formulation: Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol
Purification: By protein-G affinity chromatography
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: AKR1C1
Gene ID: 1645
Uniprot ID: AK1C1_HUMAN
Immunogen Region: 1-323aa
Accession Number: NP_001344
Immunogen: Recombinant human AKR1C1 (1-323aa) purified from E. coli
Tissue Specificity Expressed in all tissues tested including liver, prostate, testis, adrenal gland, brain, uterus, mammary gland and keratinocytes. Highest levels found in liver, mammary gland and brain.
Function Cytosolic aldo-keto reductase that catalyzes the NADH and NADPH-dependent reduction of ketosteroids to hydroxysteroids. Most probably acts as a reductase in vivo since the oxidase activity measured in vitro is inhibited by physiological concentrations of NADPH. Displays a broad positional specificity acting on positions 3, 17 and 20 of steroids and regulates the metabolism of hormones like estrogens and androgens. May also reduce conjugated steroids such as 5alpha-dihydrotestosterone sulfate. Displays affinity for bile acids.
Protein Name Aldo-Keto Reductase Family 1 Member C1
20-Alpha-Hydroxysteroid Dehydrogenase
20-Alpha-Hsd
Chlordecone Reductase Homolog Hakrc
Dihydrodiol Dehydrogenase 1
Dd1
High-Affinity Hepatic Bile Acid-Binding Protein
Hbab
Database Links Reactome: R-HSA-193368
Reactome: R-HSA-193775
Reactome: R-HSA-193807
Reactome: R-HSA-975634
Reactome: R-HSA-9757110
Cellular Localisation Cytoplasm
Cytosol
Alternative Antibody Names Anti-Aldo-Keto Reductase Family 1 Member C1 antibody
Anti-20-Alpha-Hydroxysteroid Dehydrogenase antibody
Anti-20-Alpha-Hsd antibody
Anti-Chlordecone Reductase Homolog Hakrc antibody
Anti-Dihydrodiol Dehydrogenase 1 antibody
Anti-Dd1 antibody
Anti-High-Affinity Hepatic Bile Acid-Binding Protein antibody
Anti-Hbab antibody
Anti-AKR1C1 antibody
Anti-DDH antibody
Anti-DDH1 antibody

Information sourced from Uniprot.org

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