Anti-ALAS1 antibody (541-640) [S0MR] (STJ11102160)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit monoclonal ALAS1 (541-640) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | S0MR |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ALAS1 |
| Gene ID | 211 |
| Uniprot ID | HEM1_HUMAN |
| Immunogen Region | 541-640 |
| Immunogen Sequence | TEVCDELMSRHNIYVQAINY PTVPRGEELLRIAPTPHHTP QMMNYFLENLLVTWKQVGLE LKPHSSAECNFCRRPLHFEV MSEREKSYFSGLSKLVSAQA |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 541-640 of human ALAS1 (P13196). |
Additional Info
| Post Translational Modifications | In normoxia, is hydroxylated at Pro-576, promoting interaction with VHL, initiating ubiquitination and subsequent degradation via the proteasome. Ubiquitinated.in normoxia following hydroxylation and interaction with VHL, leading to its subsequent degradation via the proteasome. |
| Function | Catalyzes the pyridoxal 5'-phosphate (PLP)-dependent condensation of succinyl-CoA and glycine to form aminolevulinic acid (ALA), with CoA and CO2 as by-products. |
| Protein Name | 5-Aminolevulinate Synthase - Non-Specific - MitochondrialAlas-H5-Aminolevulinic Acid Synthase 1Delta-Ala Synthase 1Delta-Aminolevulinate Synthase 1 |
| Database Links | Reactome: R-HSA-189451Reactome: R-HSA-1989781Reactome: R-HSA-2151201Reactome: R-HSA-9837999 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinLocalizes To The Matrix Side Of The Mitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-5-Aminolevulinate Synthase - Non-Specific - Mitochondrial antibodyAnti-Alas-H antibodyAnti-5-Aminolevulinic Acid Synthase 1 antibodyAnti-Delta-Ala Synthase 1 antibodyAnti-Delta-Aminolevulinate Synthase 1 antibodyAnti-ALAS1 antibodyAnti-ALAS3 antibodyAnti-ALASH antibodyAnti-OK antibodyAnti-SW-cl.121 antibody |
Information sourced from Uniprot.org