| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | AKR7A3 |
| Gene ID: | 22977 |
| Uniprot ID: | ARK73_HUMAN |
| Immunogen Region: | 1-331 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-331 of human AKR7A3 (NP_036199.2). |
| Immunogen Sequence: | MSRQLSRARPATVLGAMEMG RRMDAPTSAAVTRAFLERGH TEIDTAFVYSEGQSETILGG LGLRLGGSDCRVKIDTKAIP LFGNSLKPDSLRFQLETSLK RLQCPRVDLFYLHMPDHSTP VEETLRACHQLHQEGKFVEL GLSNYAAWEVAEICTLCKSN GWILPTVYQGMYNAITRQVE TELFPCLRHFGLRFYAFNPL AGGLLTGKYKYEDKNGKQPV GRFFGNTWAEMYRNRYWKE |
| Tissue Specificity | Expressed in colon, kidney, liver, pancreas, adenocarcinoma and endometrium. |
| Function | Catalyzes the NADPH-dependent reduction of various carbonyl-containing compounds, including aldehydes, ketones, and toxic products from cellular metabolism or environmental exposure. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates. Can reduce the dialdehyde form of aflatoxin B1 (AFB1) into alcohol derivatives, via monoaldehydes intermediates, thus preventing the formation of protein adducts that contribute to AFB1-induced toxicity. |
| Protein Name | Aldo-Keto Reductase Family 7 Member A3Afb1 Aldehyde Reductase 2Afb1-Ar 2Aflatoxin B1 Aldehyde Reductase Member 3 |
| Database Links | Reactome: R-HSA-5423646 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Aldo-Keto Reductase Family 7 Member A3 antibodyAnti-Afb1 Aldehyde Reductase 2 antibodyAnti-Afb1-Ar 2 antibodyAnti-Aflatoxin B1 Aldehyde Reductase Member 3 antibodyAnti-AKR7A3 antibodyAnti-AFAR2 antibody |
Information sourced from Uniprot.org
