| Function | Catalyzes the stereospecific NADPH-dependent reduction of the C4-C5 double bond of bile acid intermediates and steroid hormones carrying a delta(4)-3-one structure to yield an A/B cis-ring junction. This cis-configuration is crucial for bile acid biosynthesis and plays important roles in steroid metabolism. Capable of reducing a broad range of delta-(4)-3-ketosteroids from C18 (such as, 17beta-hydroxyestr-4-en-3-one) to C27 (such as, 7alpha-hydroxycholest-4-en-3-one). |
| Protein Name | Aldo-Keto Reductase Family 1 Member D13-Oxo-5-Beta-Steroid 4-DehydrogenaseDelta(4-3-Ketosteroid 5-Beta-ReductaseDelta(4-3-Oxosteroid 5-Beta-Reductase |
| Database Links | Reactome: R-HSA-193368Reactome: R-HSA-193775Reactome: R-HSA-193807 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Aldo-Keto Reductase Family 1 Member D1 antibodyAnti-3-Oxo-5-Beta-Steroid 4-Dehydrogenase antibodyAnti-Delta(4-3-Ketosteroid 5-Beta-Reductase antibodyAnti-Delta(4-3-Oxosteroid 5-Beta-Reductase antibodyAnti-AKR1D1 antibodyAnti-SRD5B1 antibody |
Information sourced from Uniprot.org
