• Immunohistochemistry of human tissue with Anti-AKR1B1 primary antibody (STJ500066) at 1:100 dilution in Buffer. Section was treated with DAB and Haematoxylin stain.

Anti-AKR1B1 antibody (250-350) (STJ500066)

SKU:
STJ500066-100

£441.50
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Host: Rabbit
Applications: ELISA/IHC/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-AKR1B1 (250-350) is suitable for use in ELISA, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.50 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: AKR1B1
Gene ID: 231
Uniprot ID: ALDR_HUMAN
Immunogen Region: 250-350
Immunogen: Synthetic peptide taken within amino acid region 250-350 on human Aldo-keto reductase family 1, member B1 protein.
Tissue Specificity Highly expressed in embryonic epithelial cells (EUE) in response to osmotic stress.
Function Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosacharides, bile acids and xenobiotics substrates. Key enzyme in the polyol pathway, catalyzes reduction of glucose to sorbitol during hyperglycemia. Reduces steroids and their derivatives and prostaglandins. Displays low enzymatic activity toward all-trans-retinal, 9-cis-retinal, and 13-cis-retinal. Catalyzes the reduction of diverse phospholipid aldehydes such as 1-palmitoyl-2-(5-oxovaleroyl)-sn -glycero-3-phosphoethanolamin (POVPC) and related phospholipid aldehydes that are generated from the oxydation of phosphotidylcholine and phosphatdyleethanolamides. Plays a role in detoxifying dietary and lipid-derived unsaturated carbonyls, such as crotonaldehyde, 4-hydroxynonenal, trans-2-hexenal, trans-2,4-hexadienal and their glutathione-conjugates carbonyls (GS-carbonyls).
Protein Name Aldo-Keto Reductase Family 1 Member B1
Aldehyde Reductase
Aldose Reductase
Ar
Database Links Reactome: R-HSA-196108
Reactome: R-HSA-5652227
Cellular Localisation Cytoplasm
Alternative Antibody Names Anti-Aldo-Keto Reductase Family 1 Member B1 antibody
Anti-Aldehyde Reductase antibody
Anti-Aldose Reductase antibody
Anti-Ar antibody
Anti-AKR1B1 antibody
Anti-ALDR1 antibody
Anti-ALR2 antibody

Information sourced from Uniprot.org

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