| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Aldo-keto reductase family 1 member A1 (250-330 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
AKR1A1 |
| Gene ID: |
10327 |
| Uniprot ID: |
AK1A1_HUMAN |
| Immunogen Region: |
250-330 aa |
| Specificity: |
AKR1A1 Polyclonal Antibody detects endogenous levels of AKR1A1 protein. |
| Immunogen: |
Synthesized peptide derived from AKR1A1 at the amino acid range 250-330 |
| Function | Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved also in the detoxification of lipid-derived aldehydes like acrolein. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Displays no reductase activity towards retinoids. |
| Protein Name | Aldo-Keto Reductase Family 1 Member A1 Alcohol Dehydrogenase Nadp(+Aldehyde ReductaseGlucuronate ReductaseGlucuronolactone Reductase |
| Database Links | Reactome: R-HSA-156590Reactome: R-HSA-5661270 |
| Cellular Localisation | CytoplasmCytosolApical Cell Membrane |
| Alternative Antibody Names | Anti-Aldo-Keto Reductase Family 1 Member A1 antibodyAnti-Alcohol Dehydrogenase Nadp(+ antibodyAnti-Aldehyde Reductase antibodyAnti-Glucuronate Reductase antibodyAnti-Glucuronolactone Reductase antibodyAnti-AKR1A1 antibodyAnti-ALDR1 antibodyAnti-ALR antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
