| Post Translational Modifications | Phosphorylated.phosphorylation regulates dissociation from and reassembly at the centrosome. |
| Function | Centrosomal protein that plays a key role in cell delamination by regulating microtubule organization. Required for the delamination and retention of neural stem cells from the subventricular zone during neurogenesis. Also regulates the epithelial-to-mesenchymal transition in other epithelial cells. Acts by increasing centrosomal microtubule nucleation and recruiting nucleation factors and minus-end stabilizers, thereby destabilizing microtubules at the adherens junctions and mediating constriction of the apical endfoot. In addition, may also act as a transcription factor that specifically activates the expression of the CD40 receptor and its ligand CD40L/CD154, two cell surface molecules on lymphocytes that are critical for antigen-dependent-B-cell development. Binds to A/T-rich promoters. It is unclear how it can both act as a microtubule organizer and as a transcription factor.additional evidences are required to reconcile these two apparently contradictory functions (Probable). |
| Protein Name | Microtubule Organization Protein AknaAt-Hook-Containing Transcription Factor |
| Cellular Localisation | CytoplasmCytoskeletonMicrotubule Organizing CenterCentrosomeCentrioleNucleusLocalizes To The Distal Part Of The Subdistal Appendages Of The Mother Centriole In InterphaseAlso Found At The Proximal Ends Of Centrioles And Along MicrotubulesThe Centrosomal Localization Is Dependent On CentriolesDissociates From Centrosomes During M-Phase Without Proteolytic Degradation And Reassembles At The Centrosomes During Late Telophase And Early G1 PhaseDissociation And Reassembly Is Regulated By Phosphorylation |
| Alternative Antibody Names | Anti-Microtubule Organization Protein Akna antibodyAnti-At-Hook-Containing Transcription Factor antibodyAnti-AKNA antibodyAnti-KIAA1968 antibody |
Information sourced from Uniprot.org
