| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
AKAP13 |
| Gene ID: |
11214 |
| Uniprot ID: |
AKP13_HUMAN |
| Immunogen Region: |
1-150 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human AKAP13 (NP_006729.4). |
| Immunogen Sequence: |
MKLNPQQAPLYGDCVVTVLL AEEDKAEDDVVFYLVFLGST LRHCTSTRKVSSDTLETIAP GHDCCETVKVQLCASKEGLP VFVVAEEDFHFVQDEAYDAA QFLATSAGNQQALNFTRFLD QSGPPSGDVNSLDKKLVLAF RHLKLPTEWN |
| Tissue Specificity | Detected in mammary gland. Detected in heart (at protein level). Expressed as a 5.3 kb transcript in hematopoietic cells, skeletal muscle, lung, heart, estrogen-responsive reproductive tissues, including breast ductal epithelium. Also found in testis and breast cancer cell lines. Predominantly expressed as a 10 kb transcript in the heart and at lower levels in the lung, placenta, kidney, pancreas, skeletal muscle and liver. Transcripts of between 6-9 kb are also expressed in myeloid and lymphoid lineages, a variety of epithelial tissues, and in skeletal muscle. |
| Function | Scaffold protein that plays an important role in assembling signaling complexes downstream of several types of G protein-coupled receptors. Activates RHOA in response to signaling via G protein-coupled receptors via its function as Rho guanine nucleotide exchange factor. May also activate other Rho family members. Part of a kinase signaling complex that links ADRA1A and ADRA1B adrenergic receptor signaling to the activation of downstream p38 MAP kinases, such as MAPK11 and MAPK14. Part of a signaling complex that links ADRA1B signaling to the activation of RHOA and IKBKB/IKKB, leading to increased NF-kappa-B transcriptional activity. Part of a RHOA-dependent signaling cascade that mediates responses to lysophosphatidic acid (LPA), a signaling molecule that activates G-protein coupled receptors and potentiates transcriptional activation of the glucocorticoid receptor NR3C1. Part of a signaling cascade that stimulates MEF2C-dependent gene expression in response to lysophosphatidic acid (LPA). Part of a signaling pathway that activates MAPK11 and/or MAPK14 and leads to increased transcription activation of the estrogen receptors ESR1 and ESR2. Part of a signaling cascade that links cAMP and EGFR signaling to BRAF signaling and to PKA-mediated phosphorylation of KSR1, leading to the activation of downstream MAP kinases, such as MAPK1 or MAPK3. Functions as a scaffold protein that anchors cAMP-dependent protein kinase (PKA) and PRKD1. This promotes activation of PRKD1, leading to increased phosphorylation of HDAC5 and ultimately cardiomyocyte hypertrophy. Has no guanine nucleotide exchange activity on CDC42, Ras or Rac. Required for normal embryonic heart development, and in particular for normal sarcomere formation in the developing cardiomyocytes. Plays a role in cardiomyocyte growth and cardiac hypertrophy in response to activation of the beta-adrenergic receptor by phenylephrine or isoproterenol. Required for normal adaptive cardiac hypertrophy in response to pressure overload. Plays a role in osteogenesis. |
| Protein Name | A-Kinase Anchor Protein 13Akap-13Akap-LbcBreast Cancer Nuclear Receptor-Binding Auxiliary ProteinGuanine Nucleotide Exchange Factor LbcHuman Thyroid-Anchoring Protein 31Lymphoid Blast Crisis OncogeneLbc OncogeneNon-Oncogenic Rho Gtpase-Specific Gtp Exchange FactorProtein Kinase A-Anchoring Protein 13Prka13P47 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106 |
| Cellular Localisation | CytoplasmCytosolCell CortexNucleusMembranePeripheral Membrane ProteinColocalizes With The Actin Cytoskeleton At The Cell Cortex |
| Alternative Antibody Names | Anti-A-Kinase Anchor Protein 13 antibodyAnti-Akap-13 antibodyAnti-Akap-Lbc antibodyAnti-Breast Cancer Nuclear Receptor-Binding Auxiliary Protein antibodyAnti-Guanine Nucleotide Exchange Factor Lbc antibodyAnti-Human Thyroid-Anchoring Protein 31 antibodyAnti-Lymphoid Blast Crisis Oncogene antibodyAnti-Lbc Oncogene antibodyAnti-Non-Oncogenic Rho Gtpase-Specific Gtp Exchange Factor antibodyAnti-Protein Kinase A-Anchoring Protein 13 antibodyAnti-Prka13 antibodyAnti-P47 antibodyAnti-AKAP13 antibodyAnti-BRX antibodyAnti-HT31 antibodyAnti-LBC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
