| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | AKAP12 |
| Gene ID: | 9590 |
| Uniprot ID: | AKA12_HUMAN |
| Immunogen Region: | 680-900 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 680-900 of human AKAP12 (NP_005091.2). |
| Immunogen Sequence: | EALICVGSSKKRARRGSSSD EEGGPKAMGGDHQKADEAGK DKETGTDGILAGSQEHDPGQ GSSSPEQAGSPTEGEGVSTW ESFKRLVTPRKKSKSKLEEK SEDSIAGSGVEHSTPDTEPG KEESWVSIKKFIPGRRKKRP DGKQEQAPVEDAGPTGANED DSDVPAVVPLSEYDAVEREK MEAQQAQKSAEQPEQKAATE VSKELSESQVHMMAAAVADG T |
| Tissue Specificity | Expressed in endothelial cells, cultured fibroblasts and osteosarcoma, but not in platelets, leukocytes, monocytic cell lines or peripherical blood cells. |
| Function | Anchoring protein that mediates the subcellular compartmentation of protein kinase A (PKA) and protein kinase C (PKC). |
| Protein Name | A-Kinase Anchor Protein 12Akap-12A-Kinase Anchor Protein 250 KdaAkap 250GravinMyasthenia Gravis Autoantigen |
| Database Links | Reactome: R-HSA-9013405Reactome: R-HSA-9035034 |
| Cellular Localisation | CytoplasmCell CortexCytoskeletonMembraneLipid-AnchorMay Be Part Of The Cortical Cytoskeleton |
| Alternative Antibody Names | Anti-A-Kinase Anchor Protein 12 antibodyAnti-Akap-12 antibodyAnti-A-Kinase Anchor Protein 250 Kda antibodyAnti-Akap 250 antibodyAnti-Gravin antibodyAnti-Myasthenia Gravis Autoantigen antibodyAnti-AKAP12 antibodyAnti-AKAP250 antibody |
Information sourced from Uniprot.org