Anti-AICDA antibody (81-130 aa) (STJ97261)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the Internal region of human AICDA at the amino acid range 81-130
General Information
| Short Description | Rabbit polyclonal anti-Single-stranded DNA cytosine deaminase (81-130 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC-P 1:100-1:300ELISA 1:10000IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | AICDA |
| Gene ID | 57379 |
| Uniprot ID | AICDA_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the Internal region of human AICDA at the amino acid range 81-130 |
| Immunogen Region | 81-130 aa |
| Specificity | AID Polyclonal Antibody detects endogenous levels of AID protein. |
Additional Info
| Post Translational Modifications | Ser-38 is the major site whereas Thr-27 is the minor site of phosphorylation. Phosphorylation regulates its class-switch recombination activity. Probably monoubiquitinated on several residues by RNF126. |
| Function | Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. |
| Protein Name | Single-Stranded Dna Cytosine DeaminaseActivation-Induced Cytidine DeaminaseAidCytidine Aminohydrolase |
| Database Links | Reactome: R-HSA-9821002 |
| Cellular Localisation | NucleusCytoplasmCytosolPredominantly CytosolicIn The Presence Of Mcm3ap/GanpRelocalizes To The Nucleus |
| Alternative Antibody Names | Anti-Single-Stranded Dna Cytosine Deaminase antibodyAnti-Activation-Induced Cytidine Deaminase antibodyAnti-Aid antibodyAnti-Cytidine Aminohydrolase antibodyAnti-AICDA antibodyAnti-AID antibody |
Information sourced from Uniprot.org