| Host: |
Rabbit |
| Applications: |
ELISA |
| Reactivity: |
Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: |
Affinity purification |
| Concentration: |
Lot specific |
| Dilution Range: |
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: |
AHI1 |
| Gene ID: |
54806 |
| Uniprot ID: |
AHI1_HUMAN |
| Immunogen Region: |
1-260 aa |
| Specificity: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-260 of human AHI1 (NP_001128304.1). |
| Immunogen Sequence: |
MPTAESEAKVKTKVRFEELL KTHSDLMREKKKLKKKLVRS EENISPDTIRSNLHYMKETT SDDPDTIRSNLPHIKETTSD DVSAANTNNLKKSTRVTKNK LRNTQLATENPNGDASVEED KQGKPNKKVIKTVPQLTTQD LKPETPENKVDSTHQKTHTK PQPGVDHQKSEKANEGREET DLEEDEELMQAYQCHVTEEM AKEIKRKIRKKLKEQLTYFP SDTLFHDDKLSSEKRKKKK |
| Tissue Specificity | Highly expressed in the most primitive normal hematopoietic cells. Expressed in brain, particularly in neurons that give rise to the crossing axons of the corticospinal tract and superior cerebellar peduncles. Expressed in kidney (renal collecting duct cells) (at protein level). |
| Function | Involved in vesicle trafficking and required for ciliogenesis, formation of primary non-motile cilium, and recruitment of RAB8A to the basal body of primary cilium. Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in neuronal differentiation. As a positive modulator of classical Wnt signaling, may play a crucial role in ciliary signaling during cerebellum embryonic development. |
| Protein Name | JouberinAbelson Helper Integration Site 1 Protein HomologAhi-1 |
| Database Links | Reactome: R-HSA-5620912 |
| Cellular Localisation | CytoplasmCytoskeletonCilium Basal BodyCell JunctionAdherens JunctionMicrotubule Organizing CenterCentrosomeCentrioleIn The Retinal Photoreceptor Cell LayerLocalizes At The Connecting Cilium |
| Alternative Antibody Names | Anti-Jouberin antibodyAnti-Abelson Helper Integration Site 1 Protein Homolog antibodyAnti-Ahi-1 antibodyAnti-AHI1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
