Anti-AGRP/Agouti-related protein antibody (C-Term) (STJ70688)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-AGRP/Agouti-related protein (C-Term) is suitable for use in ELISA and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IHC |
| Host | Goat |
| Reactivity | Human/Dog/Pig |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:32000.WB: Preliminary experiments gave bands at approx 45kDa and 24kDa in Human Brain lysates after 0.1µg/ml antibody staining. Thiese bands were successfully blocked by incubation with the immu |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | AGRP |
| Gene ID | 181 |
| Uniprot ID | AGRP_HUMAN |
| Accession Number | NP_001129.1; NP_015531.1 |
| Immunogen Region | C-Term |
| Immunogen Sequence | CRKLGTAMNPCSRT |
| Specificity | This antibody is expected to recognise both reported isoforms (as represented by NP_001129; NP_015531) |
Additional Info
| Function | Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. |
| Protein Name | Agouti-Related Protein |
| Database Links | Reactome: R-HSA-9615017 |
| Cellular Localisation | SecretedGolgi Apparatus Lumen |
| Alternative Antibody Names | Anti-Agouti-Related Protein antibodyAnti-AGRP antibodyAnti-AGRT antibodyAnti-ART antibody |
Information sourced from Uniprot.org