| Short Description : | Guinea Pig polyclonal anti-Agouti related protein (82-131) for use in IHC-F in Human, Mouse, Rat and Sheep samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | IHC-F |
| Host: | Guinea Pig |
| Reactivity: | Human/Mouse/Rat/Sheep |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | Mixed |
| Conjugation: | Unconjugated |
| Purification: | Whole serum |
| Dilution Range: | IHC 1:1000-1:2000 |
| Storage Instruction: | Spin vial briefly before opening. Reconstitute in 50 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. Store lyophilized antibody at 2-8°C or lower. After reconstitution, divide into aliquots and store at-20°C, or low |
| Gene Symbol: | Agrp |
| Gene ID: | 11604 |
| Uniprot ID: | AGRP_MOUSE |
| Immunogen: | A synthetic peptide (SPRRCVRLHESCLGQQVPCCDPCATCYCRFFNAFCYCRKLGTATNLCSRT) corresponding to a region (82-131) within the carboxy domain of mouse agouti related protein. This peptide was conjugated to carrier protein to enhance the immunological respons |
| Immunogen Region: | 82-131 |
| Immunogen Sequence: | Mouse |
| Specificity: | Specificity was demonstrated by immunohistochemistry. This antibody is known to react with human, rat and sheep. Other species have not yet been tested. |
| Tissue Specificity | Expressed in arcuate nucleus and median eminence, adrenal gland (medulla), hypothalamus, testis, and lung. |
| Function | Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity. It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner. |
| Protein Name | Agouti-Related Protein |
| Database Links | |
| Cellular Localisation | SecretedGolgi Apparatus Lumen |
| Alternative Antibody Names | Anti-Agouti-Related Protein antibodyAnti-Agrp antibodyAnti-Agrt antibodyAnti-Art antibody |
Information sourced from Uniprot.org
