| Host: | Rabbit |
| Applications: | IF/ICC/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM5398 |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.09% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | IF/ICC:1:100-1:400ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PLIN2 |
| Gene ID: | 123 |
| Uniprot ID: | PLIN2_HUMAN |
| Immunogen Region: | 331-430 aa |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 331-430 of human ADRP/Perilipin 2 (NP_001113.2). |
| Immunogen Sequence: | NIQGVPQNIQDQAKHMGVMA GDIYSVFRNAASFKEVSDSL LTSSKGQLQKMKESLDDVMD YLVNNTPLNWLVGPFYPQLT ESQNAQDQGAEMDKSSQETQ |
| Tissue Specificity | Milk lipid globules. |
| Post Translational Modifications | Acylated.primarily with C14, C16 and C18 fatty acids. Phosphorylation at Tyr-232 by isoform 1 of CHKA (CHKalpha2) promotes dissociation from lipid droplets: dissociation is followed by recruitment of autophagosome machinery to lipid droplets and subsequent lipid droplet lipolysis. Polyubiquitination of Nt-acetylatable A-PLIN2 by MARCHF6 lead to degradation by 26S proteasomes. |
| Function | Structural component of lipid droplets, which is required for the formation and maintenance of lipid storage droplets. |
| Protein Name | Perilipin-2AdipophilinAdipose Differentiation-Related ProteinAdrp |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-9613354Reactome: R-HSA-9613829Reactome: R-HSA-9615710Reactome: R-HSA-9841922 |
| Cellular Localisation | MembranePeripheral Membrane ProteinLipid Droplet |
| Alternative Antibody Names | Anti-Perilipin-2 antibodyAnti-Adipophilin antibodyAnti-Adipose Differentiation-Related Protein antibodyAnti-Adrp antibodyAnti-PLIN2 antibodyAnti-ADFP antibody |
Information sourced from Uniprot.org
