| Host: |
Goat |
| Applications: |
Pep-ELISA/WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-ADRA1A (C-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
Peptide ELISA: antibody detection limit dilution 1:16000.WB: Approx 55kDa band observed in Human Heart and Prostate lysates (calculated MW of 51.5kDa according to NP_000671.2). Recommended concentration: 1-3µg/ml. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
ADRA1A |
| Gene ID: |
148 |
| Uniprot ID: |
ADA1A_HUMAN |
| Immunogen Region: |
C-Term |
| Accession Number: |
NP_000671.2 |
| Specificity: |
This antibody is expected to recognize isoform 1 (NP_000671.2) only. |
| Immunogen Sequence: |
PSLDKNHQVPTIK |
| Post Translational Modifications | C-terminal Ser or Thr residues may be phosphorylated. |
| Function | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. |
| Protein Name | Alpha-1a Adrenergic ReceptorAlpha-1a AdrenoreceptorAlpha-1a AdrenoceptorAlpha-1c Adrenergic ReceptorAlpha-Adrenergic Receptor 1c |
| Database Links | Reactome: R-HSA-390696Reactome: R-HSA-416476Reactome: R-HSA-416482 |
| Cellular Localisation | Nucleus MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmMembraneCaveolaLocation At The Nuclear Membrane Facilitates Heterooligomerization And Regulates Erk-Mediated Signaling In Cardiac MyocytesColocalizes With GnaqPlcb1 As Well As Lap2 At The Nuclear Membrane Of Cardiac Myocytes |
| Alternative Antibody Names | Anti-Alpha-1a Adrenergic Receptor antibodyAnti-Alpha-1a Adrenoreceptor antibodyAnti-Alpha-1a Adrenoceptor antibodyAnti-Alpha-1c Adrenergic Receptor antibodyAnti-Alpha-Adrenergic Receptor 1c antibodyAnti-ADRA1A antibodyAnti-ADRA1C antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
