STJ72938 (1µg/ml) staining of Human Prostate lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-ADRA1A antibody (C-Term) (STJ72938)

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STJ72938-100
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Short Description :Goat polyclonal antibody anti-ADRA1A (C-Term) is suitable for use in ELISA and Western Blot research applications.
Applications:Pep-ELISA/WB
Host:Goat
Reactivity:Human
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Concentration:0.5 mg/mL
Purification:Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Dilution Range:Peptide ELISA: antibody detection limit dilution 1:16000.
WB: Approx 55kDa band observed in Human Heart and Prostate lysates (calculated MW of 51.5kDa according to NP_000671.2). Recommended concentration: 1-3µg/ml.
Formulation:0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Storage Instruction:Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol:ADRA1A
Gene ID:148
Uniprot ID:ADA1A_HUMAN
Accession Number:NP_000671.2
Immunogen Region:C-Term
Immunogen Sequence:PSLDKNHQVPTIK
Specificity:This antibody is expected to recognize isoform 1 (NP_000671.2) only.
Post Translational Modifications C-terminal Ser or Thr residues may be phosphorylated.
Function This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes.
Protein Name Alpha-1a Adrenergic Receptor
Alpha-1a Adrenoreceptor
Alpha-1a Adrenoceptor
Alpha-1c Adrenergic Receptor
Alpha-Adrenergic Receptor 1c
Database Links Reactome: R-HSA-390696
Reactome: R-HSA-416476
Reactome: R-HSA-416482
Cellular Localisation Nucleus Membrane
Multi-Pass Membrane Protein
Cell Membrane
Cytoplasm
Membrane
Caveola
Location At The Nuclear Membrane Facilitates Heterooligomerization And Regulates Erk-Mediated Signaling In Cardiac Myocytes
Colocalizes With Gnaq
Plcb1 As Well As Lap2 At The Nuclear Membrane Of Cardiac Myocytes
Alternative Antibody Names Anti-Alpha-1a Adrenergic Receptor antibody
Anti-Alpha-1a Adrenoreceptor antibody
Anti-Alpha-1a Adrenoceptor antibody
Anti-Alpha-1c Adrenergic Receptor antibody
Anti-Alpha-Adrenergic Receptor 1c antibody
Anti-ADRA1A antibody
Anti-ADRA1C antibody

Information sourced from Uniprot.org

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