Anti-ADRA1A antibody (341-390 aa) (STJ91720)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human ADRA1A at the amino acid range 341-390
General Information
| Short Description | Rabbit polyclonal anti-Alpha-1A adrenergic receptor (341-390 aa) for use in WB, IHC, IF and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADRA1A |
| Gene ID | 148 |
| Uniprot ID | ADA1A_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human ADRA1A at the amino acid range 341-390 |
| Immunogen Region | 341-390 aa |
| Specificity | AR-Alpha 1A Polyclonal Antibody detects endogenous levels of AR-Alpha 1A protein. |
Additional Info
| Post Translational Modifications | C-terminal Ser or Thr residues may be phosphorylated. |
| Function | This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine(PE)-stimulated ERK signaling in cardiac myocytes. |
| Protein Name | Alpha-1a Adrenergic ReceptorAlpha-1a AdrenoreceptorAlpha-1a AdrenoceptorAlpha-1c Adrenergic ReceptorAlpha-Adrenergic Receptor 1c |
| Database Links | Reactome: R-HSA-390696Reactome: R-HSA-416476Reactome: R-HSA-416482 |
| Cellular Localisation | Nucleus MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasmMembraneCaveolaLocation At The Nuclear Membrane Facilitates Heterooligomerization And Regulates Erk-Mediated Signaling In Cardiac MyocytesColocalizes With GnaqPlcb1 As Well As Lap2 At The Nuclear Membrane Of Cardiac Myocytes |
| Alternative Antibody Names | Anti-Alpha-1a Adrenergic Receptor antibodyAnti-Alpha-1a Adrenoreceptor antibodyAnti-Alpha-1a Adrenoceptor antibodyAnti-Alpha-1c Adrenergic Receptor antibodyAnti-Alpha-Adrenergic Receptor 1c antibodyAnti-ADRA1A antibodyAnti-ADRA1C antibody |
Information sourced from Uniprot.org