Tissue Specificity | Expressed in the esophagus, stomach, jejunum, ileum, ileocecum, ascending colon, transverse colon, descending colon and rectum. Expressed in myocardial cells of the heart, renal tubular cells, hypothalamus, and pituitary. |
Function | Intermedin/ADM2 is a peptide hormone that plays a role as physiological regulator of gastrointestinal and cardiovascular bioactivities mediated by the CALCRL-RAMPs receptor complexes. Activates the cAMP-dependent pathway through interaction with CALCRL-RAMP3 receptor complex. |
Protein Name | Protein Adm2Intermedin Cleaved Into - Adrenomedullin-2Am2Intermedin-LongImdl - Intermedin-ShortImds |
Database Links | Reactome: R-HSA-418555Reactome: R-HSA-419812 |
Cellular Localisation | Secreted |
Alternative Antibody Names | Anti-Protein Adm2 antibodyAnti-Intermedin Cleaved Into - Adrenomedullin-2 antibodyAnti-Am2 antibodyAnti-Intermedin-Long antibodyAnti-Imdl - Intermedin-Short antibodyAnti-Imds antibodyAnti-ADM2 antibodyAnti-AM2 antibody |
Information sourced from Uniprot.org