| Function | Adrenomedullin/ADM and proadrenomedullin N-20 terminal peptide/PAMP are peptide hormones that act as potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, ADM is diuretic and natriuretic, and both ADM and PAMP inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. Adrenomedullin: ADM function is mediated by the CALCRL-RAMP2 and CALCRL-RAMP3 receptor complexes with ADM showing the highest potency for the CALCRL-RAMP2 complex. |
| Protein Name | Pro-Adrenomedullin Cleaved Into - AdrenomedullinAm - Proadrenomedullin N-20 Terminal PeptideProam N-Terminal 20 PeptidePampProam-N20 |
| Database Links | Reactome: R-HSA-418555Reactome: R-HSA-419812 |
| Cellular Localisation | Secreted |
| Alternative Antibody Names | Anti-Pro-Adrenomedullin Cleaved Into - Adrenomedullin antibodyAnti-Am - Proadrenomedullin N-20 Terminal Peptide antibodyAnti-Proam N-Terminal 20 Peptide antibodyAnti-Pamp antibodyAnti-Proam-N20 antibodyAnti-ADM antibodyAnti-AM antibody |
Information sourced from Uniprot.org
