| Tissue Specificity | Detected in brain and quadriceps muscle (at protein level). Widely expressed. Expressed in heart, kidney, liver, lung, skeletal muscle, white adipose tissue, brown adipose tissue, aorta and spleen. Weakly expressed in brain and testis. |
| Function | Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism. Required for normal glucose and fat homeostasis and for maintaining a normal body weight. ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis. Has high affinity for globular adiponectin and low affinity for full-length adiponectin. |
| Protein Name | Adiponectin Receptor Protein 1Progestin And Adipoq Receptor Family Member 1Progestin And Adipoq Receptor Family Member I |
| Database Links | Reactome: R-MMU-163680 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinLocalized To The Cell Membrane And Intracellular Organelles |
| Alternative Antibody Names | Anti-Adiponectin Receptor Protein 1 antibodyAnti-Progestin And Adipoq Receptor Family Member 1 antibodyAnti-Progestin And Adipoq Receptor Family Member I antibodyAnti-Adipor1 antibodyAnti-Parq1 antibody |
Information sourced from Uniprot.org
