• Immunohistochemical analysis of paraffin-embedded human tonsil. 1, Antibody was diluted at 1:200 (4°C overnight). 2, Tris-EDTA, pH9.0 was used for antigen retrieval. 3, Secondary antibody was diluted at 1:200 (room temperature, 45min).

Anti-ADGRV1 antibody (STJ192660)

SKU:
STJ192660

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: IHC/IF
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Adhesion G-protein coupled receptor V1 is suitable for use in Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: IHC-P 1:50-300
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ADGRV1
Gene ID: 84059
Uniprot ID: AGRV1_HUMAN
Specificity: GPR98 Polyclonal Antibody detects endogenous levels of protein.
Immunogen: Synthesized peptide derived from part of the human protein
Post Translational Modifications Autoproteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit.
Function G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Involved in the regulation of bone metabolism. ADGRV1 subunit beta: Cleaved ADGRV1 beta-subunit couples with G-alpha(i)-proteins, GNAI1/2/3, and constitutively inhibits adenylate cyclase (AC) activity with a stronger effect than full ADGRV1.
Protein Name Adhesion G-Protein Coupled Receptor V1
Adgrv1
G-Protein Coupled Receptor 98
Monogenic Audiogenic Seizure Susceptibility Protein 1 Homolog
Usher Syndrome Type-2c Protein
Very Large G-Protein Coupled Receptor 1 Cleaved Into - Adgrv1 Subunit Alpha - Adgrv1 Subunit Beta
Database Links Reactome: R-HSA-9619665
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Stereocilium Membrane
Photoreceptor Inner Segment
Localizes At The Ankle Region Of The Stereocilia
In Photoreceptors
Localizes At A Plasma Membrane Microdomain In The Apical Inner Segment That Surrounds The Connecting Cilia Called Periciliary Membrane Complex
Alternative Antibody Names Anti-Adhesion G-Protein Coupled Receptor V1 antibody
Anti-Adgrv1 antibody
Anti-G-Protein Coupled Receptor 98 antibody
Anti-Monogenic Audiogenic Seizure Susceptibility Protein 1 Homolog antibody
Anti-Usher Syndrome Type-2c Protein antibody
Anti-Very Large G-Protein Coupled Receptor 1 Cleaved Into - Adgrv1 Subunit Alpha - Adgrv1 Subunit Beta antibody
Anti-ADGRV1 antibody
Anti-GPR98 antibody
Anti-KIAA0686 antibody
Anti-KIAA1943 antibody
Anti-MASS1 antibody
Anti-VLGR1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance