Anti-ADGRG2 antibody (STJ192657)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from part of the human protein
General Information
| Short Description | Rabbit polyclonal anti-Adhesion G-protein coupled receptor G2 for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADGRG2 |
| Gene ID | 10149 |
| Uniprot ID | AGRG2_HUMAN |
| Immunogen | Synthesized peptide derived from part of the human protein |
| Specificity | GPR64 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. Highly glycosylated. |
| Function | Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as dehydroepiandrosterone (DHEA.also named 3beta-hydroxyandrost-5-en-17-one) and androstenedione. Involved in a signal transduction pathway controlling epididymal function and male fertility. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG2 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Also able to couple with G(q) G proteins in vitro. Together with CFTR, required to promote fluid reabsorption within efferent ductule. |
| Protein Name | Adhesion G-Protein Coupled Receptor G2G-Protein Coupled Receptor 64Human Epididymis-Specific Protein 6He6 Cleaved Into - Adhesion G-Protein Coupled Receptor G2 - N-Terminal FragmentAdgrg2 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor G2 - C-Terminal FragmentAdgrg2 C-Terminal Fragment |
| Database Links | |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adhesion G-Protein Coupled Receptor G2 antibodyAnti-G-Protein Coupled Receptor 64 antibodyAnti-Human Epididymis-Specific Protein 6 antibodyAnti-He6 Cleaved Into - Adhesion G-Protein Coupled Receptor G2 - N-Terminal Fragment antibodyAnti-Adgrg2 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor G2 - C-Terminal Fragment antibodyAnti-Adgrg2 C-Terminal Fragment antibodyAnti-ADGRG2 antibodyAnti-GPR64 antibodyAnti-HE6 antibodyAnti-TM7LN2 antibody |
Information sourced from Uniprot.org