| Post Translational Modifications | Proteolytically cleaved into 2 subunits, an extracellular subunit and a seven-transmembrane subunit. Highly glycosylated. |
| Function | Adhesion G-protein coupled receptor (aGPCR) for steroid hormones, such as dehydroepiandrosterone (DHEA.also named 3beta-hydroxyandrost-5-en-17-one) and androstenedione. Involved in a signal transduction pathway controlling epididymal function and male fertility. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG2 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Also able to couple with G(q) G proteins in vitro. Together with CFTR, required to promote fluid reabsorption within efferent ductule. |
| Protein Name | Adhesion G-Protein Coupled Receptor G2G-Protein Coupled Receptor 64Human Epididymis-Specific Protein 6He6 Cleaved Into - Adhesion G-Protein Coupled Receptor G2 - N-Terminal FragmentAdgrg2 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor G2 - C-Terminal FragmentAdgrg2 C-Terminal Fragment |
| Database Links | |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adhesion G-Protein Coupled Receptor G2 antibodyAnti-G-Protein Coupled Receptor 64 antibodyAnti-Human Epididymis-Specific Protein 6 antibodyAnti-He6 Cleaved Into - Adhesion G-Protein Coupled Receptor G2 - N-Terminal Fragment antibodyAnti-Adgrg2 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor G2 - C-Terminal Fragment antibodyAnti-Adgrg2 C-Terminal Fragment antibodyAnti-ADGRG2 antibodyAnti-GPR64 antibodyAnti-HE6 antibodyAnti-TM7LN2 antibody |
Information sourced from Uniprot.org
