| Post Translational Modifications | Autoproteolytically cleaved into 2 fragments.the large extracellular N-terminal fragment (ADGRG1 NT) and the membrane-bound C-terminal fragment (ADGRG1 CT) predominantly remain associated and non-covalently linked. Shedding to yield the secreted ADGRG1 N-terminal fragment seems to involve metalloprotease(s). N-glycosylated. Contains sialic acid residues. Ubiquitinated. Undergoes polyubiquitination upon activation. |
| Function | Adhesion G-protein coupled receptor (aGPCR) for steroid hormone 17alpha-hydroxypregnenolone (17-OH), which is involved in cell adhesion and cell-cell interactions. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as RhoA pathway. ADGRG1 is coupled to G(12) and/or G(13) G proteins (GNA12 and GNA13, respectively) and mediates the activation Rho small GTPases. Acts as a potent suppressor of ferroptosis: binding to 17-OH-binding initiates signaling that down-regulates CD36 and alleviates ferroptosis-induced liver injury. Ligand-binding also induces cell adhesion activity via association with proteins such as collagen III/COL3A1 and TGM2. Mediates cell matrix adhesion in developing neurons and hematopoietic stem cells. Involved in cortical development, specifically in maintenance of the pial basement membrane integrity and in cortical lamination: association with COL3A1 in the developing brain inhibits neuronal migration via activation of the RhoA pathway. Together with TGM2, acts as a regulator of myelination and myelin repair in oligodendrocyte precursor cells. Acts as a hemostatic sensor of shear force: G protein-coupled receptor signaling is activated in response to shear force in platelets, promoting G(13) G protein signaling, and platelet shape change and aggregation in a COL3A1-dependent manner. Acts as an inhibitor of VEGFA production thereby inhibiting angiogenesis through a signaling pathway mediated by PRKCA. Plays a role in the maintenance of hematopoietic stem cells in bone marrow niche. Plays an essential role in testis development. |
| Protein Name | Adhesion G-Protein Coupled Receptor G1G-Protein Coupled Receptor 56 Cleaved Into - Adhesion G-Protein Coupled Receptor G1 - N-Terminal FragmentAdgrg1 N-Terminal FragmentAdgrg1 NtGpr56 N-Terminal FragmentGpr56 NtGpr56(NGpr56 Extracellular SubunitGpr56 Subunit Alpha - Adhesion G-Protein Coupled Receptor G1 - C-Terminal FragmentAdgrg1 C-Terminal FragmentAdgrg1 CtGpr56 C-Terminal FragmentGpr56 CtGpr56(CGpr56 Seven-Transmembrane SubunitGpr56 7tmGpr56 Subunit Beta |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinAdhesion G-Protein Coupled Receptor G1N-Terminal Fragment: SecretedActivation Of The G Protein-Coupled Receptor And Interaction With Col3a1 Leads To The Release Of Adgrg1 Nt From The MembraneC-Terminal Fragment: Membrane RaftInteraction With Its Ligand Col3a1 Leads To The Release Of Adgrg1 Nt From The Membrane And Triggers The Association Of Adgrg1 Ct With Lipid Rafts |
| Alternative Antibody Names | Anti-Adhesion G-Protein Coupled Receptor G1 antibodyAnti-G-Protein Coupled Receptor 56 Cleaved Into - Adhesion G-Protein Coupled Receptor G1 - N-Terminal Fragment antibodyAnti-Adgrg1 N-Terminal Fragment antibodyAnti-Adgrg1 Nt antibodyAnti-Gpr56 N-Terminal Fragment antibodyAnti-Gpr56 Nt antibodyAnti-Gpr56(N antibodyAnti-Gpr56 Extracellular Subunit antibodyAnti-Gpr56 Subunit Alpha - Adhesion G-Protein Coupled Receptor G1 - C-Terminal Fragment antibodyAnti-Adgrg1 C-Terminal Fragment antibodyAnti-Adgrg1 Ct antibodyAnti-Gpr56 C-Terminal Fragment antibodyAnti-Gpr56 Ct antibodyAnti-Gpr56(C antibodyAnti-Gpr56 Seven-Transmembrane Subunit antibodyAnti-Gpr56 7tm antibodyAnti-Gpr56 Subunit Beta antibodyAnti-ADGRG1 antibodyAnti-GPR56 antibodyAnti-TM7LN4 antibodyAnti-TM7XN1 antibodyAnti-UNQ540 antibodyAnti-PRO1083 antibody |
Information sourced from Uniprot.org
