| Post Translational Modifications | Highly glycosylated. Proteolytically cleaved at multiple sites: one in the GPS region of the GAIN-B domain (S1 site) and the other in the SEA domain (S2 site). The proteolytic cleavage at S1 site generates an extracellular subunit and a seven-transmembrane subunit. The proteolytic cleavage at S2 site generates a fragment that undergoes proteolytic cleavage by the processing enzyme furin. |
| Function | Adhesion G protein-coupled receptor. In alveolar type II (ATII or AT2) cells, required for normal lung surfactant homeostasis. Modulation of both surfactant secretion and uptake by ATII cells is mediated by the downstream activation of GNAQ/GNA11 proteins and may be a consequence of increased cortical F-actin assembly induced by ADGRF5 activation. In the kidney, may play a role in the regulation of acid excretion into the primary urine, possibly by regulating the surface expression of V-ATPase proton pump. As a receptor for soluble FNDC4 (sFNDC4), required for proper systemic glucose tolerance, specifically sensitizing white adipose tissue to insulin. Plays also a role in sFNDC4-induced decrease of local inflammation in white adipose tissue. |
| Protein Name | Adhesion G Protein-Coupled Receptor F5G-Protein Coupled Receptor 116 |
| Database Links | Reactome: R-HSA-5683826 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adhesion G Protein-Coupled Receptor F5 antibodyAnti-G-Protein Coupled Receptor 116 antibodyAnti-ADGRF5 antibodyAnti-GPR116 antibodyAnti-KIAA0758 antibody |
Information sourced from Uniprot.org
