Anti-ADGRB1/BAI1 antibody [SAA1787] (STJA0020215)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Adhesion G Protein-Coupled Receptor B1 antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1787 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | ADGRB1 |
| Gene ID | 575 |
| Uniprot ID | AGRB1_HUMAN |
Additional Info
| Post Translational Modifications | Proteolytically cleaved to produce vasculostatin-40 and vasculostatin-120. Vasculostatin-40 is the major form and is produced through proteolytic cleavage by MMP14 between residues 321 and 329 with cleavage likely to be between Ser-326 and Leu-327. Ubiquitinated. |
| Function | Phosphatidylserine receptor which enhances the engulfment of apoptotic cells. Also mediates the binding and engulfment of Gram-negative bacteria. Stimulates production of reactive oxygen species by macrophages in response to Gram-negative bacteria, resulting in enhanced microbicidal macrophage activity. In the gastric mucosa, required for recognition and engulfment of apoptotic gastric epithelial cells. Promotes myoblast fusion. Activates the Rho pathway in a G-protein-dependent manner. Inhibits MDM2-mediated ubiquitination and degradation of DLG4/PSD95, promoting DLG4 stability and regulating synaptic plasticity. Required for the formation of dendritic spines by ensuring the correct localization of PARD3 and TIAM1. Potent inhibitor of angiogenesis in brain and may play a significant role as a mediator of the p53/TP53 signal in suppression of glioblastoma. Vasculostatin-120: Inhibits angiogenesis in a CD36-dependent manner. Vasculostatin-40: Inhibits angiogenesis. |
| Protein Name | Adhesion G Protein-Coupled Receptor B1Brain-Specific Angiogenesis Inhibitor 1 Cleaved Into - Vasculostatin-40Vstat40 - Vasculostatin-120Vstat120 |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCell ProjectionPhagocytic CupCell JunctionFocal AdhesionDendritic SpinePostsynaptic DensityVasculostatin-120: SecretedVasculostatin-40: Secreted |
| Alternative Antibody Names | Anti-Adhesion G Protein-Coupled Receptor B1 antibodyAnti-Brain-Specific Angiogenesis Inhibitor 1 Cleaved Into - Vasculostatin-40 antibodyAnti-Vstat40 - Vasculostatin-120 antibodyAnti-Vstat120 antibodyAnti-ADGRB1 antibodyAnti-BAI1 antibody |
Information sourced from Uniprot.org