Anti-Adenylate cyclase type III antibody (PAAFPNGSSVTLPHQVVDNP) (STJA0040966)

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STJA0040966-100
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Host: Rabbit
Applications: ICC/IHC/WB
Reactivity: Human/Mouse/Other Mammals/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Rabbit polyclonal anti-Adenylate cyclase type III (PAAFPNGSSVTLPHQVVDNP) for use in ICC, IHC and WB in Human, Mouse, Other Mammals and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Clonality : Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Lyophilized from PBS buffer pH 7.2-7.6 with 0.1% trehalose, and sodium azide
Purification: Affinity-purified
Dilution Range: WB 1:1000-1:2000
IHC 1:5000-1:10000
ICC 1:5000-1:10000
Storage Instruction: Spin vial briefly before opening. Reconstitute with 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. Store lyophilized, unopened vial at 2-8°C or lower. After reconstitution, prepare aliquots and store at-20°C to
Gene Symbol: Adcy3
Gene ID: 64508
Uniprot ID: ADCY3_RAT
Immunogen Region: PAAFPNGSSVTLPHQVVDNP
Specificity: The antibody stains a band at about 200 kDa in olfactory epithelium which is rich in cilia. Fewer cilia are found in frontal cortex, and the protein is less heavily glycosylated, and a less prominent band is seen at about 160 kDa. It has also been us
Immunogen: 20 amino acid peptide identical to the C-terminus of rat ACIII (amino acids PAAFPNGSSVTLPHQVVDNP)
Immunogen Sequence: Rat
Tissue Specificity Detected on cilia on the olfactory epithelium (at protein level). Detected on cilia on the olfactory epithelium.
Post Translational Modifications N-glycosylated. Sumoylated. Sumoylation is required for targeting ot olfactory cilia. Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity.
Function Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
Protein Name Adenylate Cyclase Type 3
Atp Pyrophosphate-Lyase 3
Adenylate Cyclase Type Iii
Ac-Iii
Adenylate Cyclase - Olfactive Type
Adenylyl Cyclase 3
Ac3
Database Links Reactome: R-RNO-163615
Reactome: -RNO-170660
Reactome: -RNO-170670
Reactome: -RNO-418597
Reactome: -RNO-5610787
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Golgi Apparatus
Cell Projection
Cilium
Cytoplasm
Alternative Antibody Names Anti-Adenylate Cyclase Type 3 antibody
Anti-Atp Pyrophosphate-Lyase 3 antibody
Anti-Adenylate Cyclase Type Iii antibody
Anti-Ac-Iii antibody
Anti-Adenylate Cyclase - Olfactive Type antibody
Anti-Adenylyl Cyclase 3 antibody
Anti-Ac3 antibody
Anti-Adcy3 antibody

Information sourced from Uniprot.org

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