Anti-Adenylate cyclase type III antibody (PAAFPNGSSVTLPHQVVDNP) (STJA0040966)

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STJA0040966-100
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Short Description :Rabbit polyclonal anti-Adenylate cyclase type III (PAAFPNGSSVTLPHQVVDNP) for use in ICC, IHC and WB in Human, Mouse, Other Mammals and Rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications:ICC/IHC/WB
Host:Rabbit
Reactivity:Human/Mouse/Other Mammals/Rat
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality :Polyclonal
Isotype:IgG
Conjugation:Unconjugated
Purification:Affinity-purified
Dilution Range:WB 1:1000-1:2000
IHC 1:5000-1:10000
ICC 1:5000-1:10000
Formulation:Lyophilized from PBS buffer pH 7.2-7.6 with 0.1% trehalose, and sodium azide
Storage Instruction:Spin vial briefly before opening. Reconstitute with 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. Store lyophilized, unopened vial at 2-8°C or lower. After reconstitution, prepare aliquots and store at-20°C to
Gene Symbol:Adcy3
Gene ID:64508
Uniprot ID:ADCY3_RAT
Immunogen:20 amino acid peptide identical to the C-terminus of rat ACIII (amino acids PAAFPNGSSVTLPHQVVDNP)
Immunogen Region:PAAFPNGSSVTLPHQVVDNP
Immunogen Sequence:Rat
Specificity:The antibody stains a band at about 200 kDa in olfactory epithelium which is rich in cilia. Fewer cilia are found in frontal cortex, and the protein is less heavily glycosylated, and a less prominent band is seen at about 160 kDa. It has also been us
Tissue Specificity Detected on cilia on the olfactory epithelium (at protein level). Detected on cilia on the olfactory epithelium.
Post Translational Modifications N-glycosylated. Sumoylated. Sumoylation is required for targeting ot olfactory cilia. Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity.
Function Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet.
Protein Name Adenylate Cyclase Type 3
Atp Pyrophosphate-Lyase 3
Adenylate Cyclase Type Iii
Ac-Iii
Adenylate Cyclase - Olfactive Type
Adenylyl Cyclase 3
Ac3
Database Links Reactome: R-RNO-163615
Reactome: -RNO-170660
Reactome: -RNO-170670
Reactome: -RNO-418597
Reactome: -RNO-5610787
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Golgi Apparatus
Cell Projection
Cilium
Cytoplasm
Alternative Antibody Names Anti-Adenylate Cyclase Type 3 antibody
Anti-Atp Pyrophosphate-Lyase 3 antibody
Anti-Adenylate Cyclase Type Iii antibody
Anti-Ac-Iii antibody
Anti-Adenylate Cyclase - Olfactive Type antibody
Anti-Adenylyl Cyclase 3 antibody
Anti-Ac3 antibody
Anti-Adcy3 antibody

Information sourced from Uniprot.org

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