Anti-Adenylate cyclase type III antibody (PAAFPNGSSVTLPHQVVDNP) (STJA0040966)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
Immunogen20 amino acid peptide identical to the C-terminus of rat ACIII (amino acids PAAFPNGSSVTLPHQVVDNP)
General Information
| Short Description | Rabbit polyclonal anti-Adenylate cyclase type III (PAAFPNGSSVTLPHQVVDNP) for use in ICC, IHC and WB in Human, Mouse, Other Mammals and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ICC/IHC/WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Other Mammals/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity-purified |
| Dilution Range | WB 1:1000-1:2000IHC 1:5000-1:10000ICC 1:5000-1:10000 |
| Formulation | Lyophilized from PBS buffer pH 7.2-7.6 with 0.1% trehalose, and sodium azide |
| Storage Instruction | Spin vial briefly before opening. Reconstitute with 100 µL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. Store lyophilized, unopened vial at 2-8°C or lower. After reconstitution, prepare aliquots and store at-20°C to |
Target Information
| Gene Symbol | Adcy3 |
| Gene ID | 64508 |
| Uniprot ID | ADCY3_RAT |
| Immunogen | 20 amino acid peptide identical to the C-terminus of rat ACIII (amino acids PAAFPNGSSVTLPHQVVDNP) |
| Immunogen Region | PAAFPNGSSVTLPHQVVDNP |
| Immunogen Sequence | Rat |
| Specificity | The antibody stains a band at about 200 kDa in olfactory epithelium which is rich in cilia. Fewer cilia are found in frontal cortex, and the protein is less heavily glycosylated, and a less prominent band is seen at about 160 kDa. It has also been us |
Additional Info
| Tissue Specificity | Detected on cilia on the olfactory epithelium (at protein level). Detected on cilia on the olfactory epithelium. |
| Post Translational Modifications | N-glycosylated. Sumoylated. Sumoylation is required for targeting ot olfactory cilia. Rapidly phosphorylated after stimulation by odorants or forskolin. Phosphorylation by CaMK2 at Ser-1076 down-regulates enzyme activity. |
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Participates in signaling cascades triggered by odorant receptors via its function in cAMP biosynthesis: specifically activated by G alpha protein GNAL/G(olf) in olfactory epithelium. Required for the perception of odorants. Required for normal sperm motility and normal male fertility. Plays a role in regulating insulin levels and body fat accumulation in response to a high fat diet. |
| Protein Name | Adenylate Cyclase Type 3Atp Pyrophosphate-Lyase 3Adenylate Cyclase Type IiiAc-IiiAdenylate Cyclase - Olfactive TypeAdenylyl Cyclase 3Ac3 |
| Database Links | Reactome: R-RNO-163615Reactome: -RNO-170660Reactome: -RNO-170670Reactome: -RNO-418597Reactome: -RNO-5610787 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinGolgi ApparatusCell ProjectionCiliumCytoplasm |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 3 antibodyAnti-Atp Pyrophosphate-Lyase 3 antibodyAnti-Adenylate Cyclase Type Iii antibodyAnti-Ac-Iii antibodyAnti-Adenylate Cyclase - Olfactive Type antibodyAnti-Adenylyl Cyclase 3 antibodyAnti-Ac3 antibodyAnti-Adcy3 antibody |
Information sourced from Uniprot.org