| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADCYAP1R1 |
| Gene ID: | 117 |
| Uniprot ID: | PACR_HUMAN |
| Immunogen Region: | 25-140 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-140 of ADCYAP1R1 (NP_001109.2). |
| Immunogen Sequence: | CIFKKEQAMCLEKIQRANEL MGFNDSSPGCPGMWDNITCW KPAHVGEMVLVSCPELFRIF NPDQVWETETIGESDFGDSN SLDLSDMGVVSRNCTEDGWS EPFPHYFDACGFDEYE |
| Tissue Specificity | Most abundant in the brain, low expression in the lung, liver, thymus, spleen, pancreas and placenta. |
| Function | This is a receptor for PACAP-27 and PACAP-38. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. May regulate the release of adrenocorticotropin, luteinizing hormone, growth hormone, prolactin, epinephrine, and catecholamine. May play a role in spermatogenesis and sperm motility. Causes smooth muscle relaxation and secretion in the gastrointestinal tract. |
| Protein Name | Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor Pac1 Receptor Pac1r Pacap Type I Receptor Pacap-R-1 Pacap-R1 |
| Database Links | Reactome: R-HSA-187024 Reactome: R-HSA-418555 Reactome: R-HSA-420092 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Pituitary Adenylate Cyclase-Activating Polypeptide Type I Receptor antibody Anti-Pac1 Receptor antibody Anti-Pac1r antibody Anti-Pacap Type I Receptor antibody Anti-Pacap-R-1 antibody Anti-Pacap-R1 antibody Anti-ADCYAP1R1 antibody |
Information sourced from Uniprot.org