• Immunohistochemistry of mouse kidney with Anti-ADCY7 primary antibody (STJ502059) at 1:50 dilution in Buffer. Section was treated with DAB and Haematoxylin stain. Magnification is at 40X.

Anti-ADCY7 antibody (STJ502059)

SKU:
STJ502059-100

£481.50
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Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/WB
Reactivity: Bovine/Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ADCY7 is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.75 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IP: 1:200
IHC: 1:100-1:200
ICC: 1:100-1:200
IF: 1:100-1:200
CFM: 1:100-1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Adcy7
Gene ID: 11513
Uniprot ID: ADCY7_MOUSE
Specificity: Does not cross react with other Adenylate cyclases.
Immunogen: Synthetic peptide corresponding to unique amino acid sequence on mouse Particulate Adenylyl Cyclase 7 protein.
Tissue Specificity Most abundant in heart, spleen and lung.
Post Translational Modifications Phosphorylated by PRKCD.
Function Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13. Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex. Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells.
Protein Name Adenylate Cyclase Type 7
Atp Pyrophosphate-Lyase 7
Adenylate Cyclase Type Vii
Adenylyl Cyclase 7
Database Links Reactome: R-MMU-163615
Reactome: -MMU-170660
Reactome: -MMU-170670
Reactome: -MMU-418597
Reactome: -MMU-5610787
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Antibody Names Anti-Adenylate Cyclase Type 7 antibody
Anti-Atp Pyrophosphate-Lyase 7 antibody
Anti-Adenylate Cyclase Type Vii antibody
Anti-Adenylyl Cyclase 7 antibody
Anti-Adcy7 antibody

Information sourced from Uniprot.org

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