| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADCY2 |
| Gene ID: | 108 |
| Uniprot ID: | ADCY2_HUMAN |
| Immunogen Region: | 430-600 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 430-600 of human ADCY2 (NP_065433.2). |
| Immunogen Sequence: | VTLEHLNGAYKVEEGDGDIR DPYLKQHLVKTYFVINPKGE RRSPQHLFRPRHTLDGAKMR ASVRMTRYLESWGAAKPFAH LHHRDSMTTENGKISTTDVP MGQHNFQNRTLRTKSQKKRF EEELNERMIQAIDGINAQKQ WLKSEDIQRISLLFYNKVLE KEYRATALPAF |
| Tissue Specificity | Detected in zona glomerulosa and zona fasciculata in the adrenal gland (at protein level). Expressed in brain, especially in caudate nucleus, cerebellum and hippocampus. |
| Post Translational Modifications | Phosphorylated by RAF1. |
| Function | Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. Down-stream signaling cascades mediate changes in gene expression patterns and lead to increased IL6 production. Functions in signaling cascades downstream of the muscarinic acetylcholine receptors. |
| Protein Name | Adenylate Cyclase Type 2Atp Pyrophosphate-Lyase 2Adenylate Cyclase Type IiAdenylyl Cyclase 2 |
| Database Links | Reactome: R-HSA-163359Reactome: R-HSA-163615Reactome: R-HSA-164378Reactome: R-HSA-170660Reactome: R-HSA-170670Reactome: R-HSA-418555Reactome: R-HSA-418594Reactome: R-HSA-418597Reactome: R-HSA-432040Reactome: R-HSA-5610787Reactome: R-HSA-9634597Reactome: R-HSA-9660821Reactome: R-HSA-9664323 |
| Cellular Localisation | MembraneMulti-Pass Membrane ProteinCell MembraneCytoplasm |
| Alternative Antibody Names | Anti-Adenylate Cyclase Type 2 antibodyAnti-Atp Pyrophosphate-Lyase 2 antibodyAnti-Adenylate Cyclase Type Ii antibodyAnti-Adenylyl Cyclase 2 antibodyAnti-ADCY2 antibodyAnti-KIAA1060 antibody |
Information sourced from Uniprot.org
