| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-A disintegrin and metalloproteinase with thrombospondin motifs 6 (989-1039 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADAMTS6 |
| Gene ID: | 11174 |
| Uniprot ID: | ATS6_HUMAN |
| Immunogen Region: | 989-1039 aa |
| Specificity: | This antibody detects endogenous levels of ATS6 at Human |
| Immunogen: | Synthesized peptide derived from the human ATS6 at the amino acid range 989-1039 |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 6 Adam-Ts 6 Adam-Ts6 Adamts-6 |
| Database Links | Reactome: R-HSA-5083635 Reactome: R-HSA-5173214 |
| Cellular Localisation | Secreted Extracellular Space Extracellular Matrix |
| Alternative Antibody Names | Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 6 antibody Anti-Adam-Ts 6 antibody Anti-Adam-Ts6 antibody Anti-Adamts-6 antibody Anti-ADAMTS6 antibody |
Information sourced from Uniprot.org