Anti-ADAMTS2 antibody (1029-1213) (STJ112310)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ADAMTS2 (1029-1213) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADAMTS2 |
| Gene ID | 9509 |
| Uniprot ID | ATS2_HUMAN |
| Immunogen Region | 1029-1213 |
| Immunogen Sequence | PRNISDPSKKSYVVQWLSRP DPDSPIRKISSKGHCQGDKS IFCRMEVLSRYCSIPGYNKL CCKSCNLYNNLTNVEGRIEP PPGKHNDIDVFMPTLPVPTV AMEVRPSPSTPLEVPLNASS TNATEDHPETNAVDEPYKIH GLEDEVQPPNLIPRRPSPYE KTRNQRIQELIDEMRKKEML GKF |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1029-1213 of human ADAMTS2 (O95450). |
Additional Info
| Tissue Specificity | Expressed at high level in skin, bone, tendon and aorta and at low levels in thymus and brain. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. |
| Function | Cleaves the propeptides of type I and II collagen prior to fibril assembly. Does not act on type III collagen. Cleaves lysyl oxidase LOX at a site downstream of its propeptide cleavage site to produce a short LOX form with reduced collagen-binding activity. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 2Adam-Ts 2Adam-Ts2Adamts-2Procollagen I N-ProteinasePc I-NpProcollagen I/Ii Amino Propeptide-Processing EnzymeProcollagen N-EndopeptidasePnpi |
| Database Links | Reactome: R-HSA-1650814Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 2 antibodyAnti-Adam-Ts 2 antibodyAnti-Adam-Ts2 antibodyAnti-Adamts-2 antibodyAnti-Procollagen I N-Proteinase antibodyAnti-Pc I-Np antibodyAnti-Procollagen I/Ii Amino Propeptide-Processing Enzyme antibodyAnti-Procollagen N-Endopeptidase antibodyAnti-Pnpi antibodyAnti-ADAMTS2 antibodyAnti-PCINP antibodyAnti-PCPNI antibody |
Information sourced from Uniprot.org