Anti-ADAMTS1 antibody (718-967) (STJ117551)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ADAMTS1 (718-967) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADAMTS1 |
| Gene ID | 9510 |
| Uniprot ID | ATS1_HUMAN |
| Immunogen Region | 718-967 |
| Immunogen Sequence | GGNGSTCKKISGSVTSAKPG YHDIITIPTGATNIEVKQRN QRGSRNNGSFLAIKAADGTY ILNGDYTLSTLEQDIMYKGV VLRYSGSSAALERIRSFSPL KEPLTIQVLTVGNALRPKIK YTYFVKKKKESFNAIPTFSA WVIEEWGECSKSCELGWQRR LVECRDINGQPASECAKEVK PASTRPCADHPCPQWQLGEW SSCSKTCGKGYKKRSLKCLS HDGGVLSHESCDPLKKPKH |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 718-967 of human ADAMTS1 (NP_008919.3). |
Additional Info
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. |
| Function | Metalloprotease which cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover. Also cleaves COMP. Has angiogenic inhibitor activity. May play a critical role in follicular rupture. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 1Adam-Ts 1Adam-Ts1Adamts-1Meth-1 |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 1 antibodyAnti-Adam-Ts 1 antibodyAnti-Adam-Ts1 antibodyAnti-Adamts-1 antibodyAnti-Meth-1 antibodyAnti-ADAMTS1 antibodyAnti-KIAA1346 antibodyAnti-METH1 antibody |
Information sourced from Uniprot.org