| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ADAMTS1 (718-967) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADAMTS1 |
| Gene ID: |
9510 |
| Uniprot ID: |
ATS1_HUMAN |
| Immunogen Region: |
718-967 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 718-967 of human ADAMTS1 (NP_008919.3). |
| Immunogen Sequence: |
GGNGSTCKKISGSVTSAKPG YHDIITIPTGATNIEVKQRN QRGSRNNGSFLAIKAADGTY ILNGDYTLSTLEQDIMYKGV VLRYSGSSAALERIRSFSPL KEPLTIQVLTVGNALRPKIK YTYFVKKKKESFNAIPTFSA WVIEEWGECSKSCELGWQRR LVECRDINGQPASECAKEVK PASTRPCADHPCPQWQLGEW SSCSKTCGKGYKKRSLKCLS HDGGVLSHESCDPLKKPKH |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. |
| Function | Cleaves aggrecan, a cartilage proteoglycan, at the '1938-Glu-|-Leu-1939' site (within the chondroitin sulfate attachment domain), and may be involved in its turnover. Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 1Adam-Ts 1Adam-Ts1Adamts-1Meth-1 |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 1 antibodyAnti-Adam-Ts 1 antibodyAnti-Adam-Ts1 antibodyAnti-Adamts-1 antibodyAnti-Meth-1 antibodyAnti-ADAMTS1 antibodyAnti-KIAA1346 antibodyAnti-METH1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
