![Anti-ADAM9 nanobody [SAA1216] (STJN000265)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200878/413060/STJN000265-SDS-PAGE-1__95101.1749232569.jpg?c=1 "Anti-ADAM9 nanobody [SAA1216] (STJN000265)")
![Anti-ADAM9 nanobody [SAA1216] (STJN000265)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200878/413060/STJN000265-SDS-PAGE-1__95101.1749232569.jpg?c=1 "Anti-ADAM9 nanobody [SAA1216] (STJN000265)")
Anti-ADAM9 nanobody [SAA1216] (STJN000265)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Disintegrin And Metalloproteinase Domain-Containing Protein 9 is suitable for use in ELISA research applications. |
| Applications | ELISA |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1216 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | ADAM9 |
| Gene ID | 8754 |
| Uniprot ID | ADAM9_HUMAN |
Additional Info
| Post Translational Modifications | Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9. Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA). |
| Function | Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP). |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 9Adam 9Cellular Disintegrin-Related ProteinMeltrin-GammaMetalloprotease/Disintegrin/Cysteine-Rich Protein 9Myeloma Cell Metalloproteinase |
| Database Links | Reactome: R-HSA-1442490 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Nanobody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 9 nanobodyAnti-Adam 9 nanobodyAnti-Cellular Disintegrin-Related Protein nanobodyAnti-Meltrin-Gamma nanobodyAnti-Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 nanobodyAnti-Myeloma Cell Metalloproteinase nanobodyAnti-ADAM9 nanobodyAnti-KIAA0021 nanobodyAnti-MCMP nanobodyAnti-MDC9 nanobodyAnti-MLTNG nanobody |
Information sourced from Uniprot.org