Anti-ADAM9 antibody (29-210) (STJ27341)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ADAM9 (29-210) antibody for use in WB, IF, ICC and ELISA in human, mouse, rat and monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADAM9 |
| Gene ID | 8754 |
| Uniprot ID | ADAM9_HUMAN |
| Immunogen Region | 29-210 |
| Immunogen Sequence | AARPGFQQTSHLSSYEIITP WRLTRERREAPRPYSKQVSY VIQAEGKEHIIHLERNKDLL PEDFVVYTYNKEGTLITDHP NIQNHCHYRGYVEGVHNSSI ALSDCFGLRGLLHLENASYG IEPLQNSSHFEHIIYRMDDV YKEPLKCGVSNKDIEKETAK DEEEEPPSMTQLLRRRRAVL PQ |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 29-210 of human ADAM9 (NP_003807.1). |
Additional Info
| Tissue Specificity | Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. |
| Post Translational Modifications | Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9. Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA). |
| Function | Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP). |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 9Adam 9Cellular Disintegrin-Related ProteinMeltrin-GammaMetalloprotease/Disintegrin/Cysteine-Rich Protein 9Myeloma Cell Metalloproteinase |
| Database Links | Reactome: R-HSA-1442490 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 9 antibodyAnti-Adam 9 antibodyAnti-Cellular Disintegrin-Related Protein antibodyAnti-Meltrin-Gamma antibodyAnti-Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 antibodyAnti-Myeloma Cell Metalloproteinase antibodyAnti-ADAM9 antibodyAnti-KIAA0021 antibodyAnti-MCMP antibodyAnti-MDC9 antibodyAnti-MLTNG antibody |
Information sourced from Uniprot.org