| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Disintegrin and metalloproteinase domain-containing protein 9 (120-200 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 ELISA 1:5000-20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ADAM9 |
| Gene ID: | 8754 |
| Uniprot ID: | ADAM9_HUMAN |
| Immunogen Region: | 120-200 aa |
| Specificity: | ADAM9 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 120-200 |
| Post Translational Modifications | Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9. Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA). |
| Function | Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP). |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 9 Adam 9 Cellular Disintegrin-Related Protein Meltrin-Gamma Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 Myeloma Cell Metalloproteinase |
| Database Links | Reactome: R-HSA-1442490 |
| Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 9 antibody Anti-Adam 9 antibody Anti-Cellular Disintegrin-Related Protein antibody Anti-Meltrin-Gamma antibody Anti-Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 antibody Anti-Myeloma Cell Metalloproteinase antibody Anti-ADAM9 antibody Anti-KIAA0021 antibody Anti-MCMP antibody Anti-MDC9 antibody Anti-MLTNG antibody |
Information sourced from Uniprot.org