| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Disintegrin and metalloproteinase domain-containing protein 9 (120-200 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000ELISA 1:5000-20000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADAM9 |
| Gene ID: |
8754 |
| Uniprot ID: |
ADAM9_HUMAN |
| Immunogen Region: |
120-200 aa |
| Specificity: |
ADAM9 Polyclonal Antibody detects endogenous levels of protein. |
| Immunogen: |
Synthesized peptide derived from the human protein at the amino acid range 120-200 |
| Post Translational Modifications | Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9. Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA). |
| Function | Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP). |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 9Adam 9Cellular Disintegrin-Related ProteinMeltrin-GammaMetalloprotease/Disintegrin/Cysteine-Rich Protein 9Myeloma Cell Metalloproteinase |
| Database Links | Reactome: R-HSA-1442490 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 9 antibodyAnti-Adam 9 antibodyAnti-Cellular Disintegrin-Related Protein antibodyAnti-Meltrin-Gamma antibodyAnti-Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 antibodyAnti-Myeloma Cell Metalloproteinase antibodyAnti-ADAM9 antibodyAnti-KIAA0021 antibodyAnti-MCMP antibodyAnti-MDC9 antibodyAnti-MLTNG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
