| Tissue Specificity | Ubiquitously expressed. Expressed at highest levels in adult heart, placenta, skeletal muscle, pancreas, spleen, thymus, prostate, testes, ovary and small intestine, and in fetal brain, lung, liver and kidney. Expressed in natural killer cells (at protein level). |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Phosphorylated. Stimulation by growth factor or phorbol 12-myristate 13-acetate induces phosphorylation of Ser-819 but decreases phosphorylation of Ser-791. Phosphorylation at Thr-735 by MAPK14 is required for ADAM17-mediated ectodomain shedding. |
| Function | Transmembrane metalloprotease which mediates the ectodomain shedding of a myriad of transmembrane proteins including adhesion proteins, growth factor precursors and cytokines important for inflammation and immunity. Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface. Responsible for the proteolytic release of several other cell-surface proteins, including p75 TNF-receptor, interleukin 1 receptor type II, p55 TNF-receptor, transforming growth factor-alpha, L-selectin, growth hormone receptor, MUC1 and the amyloid precursor protein. Acts as an activator of Notch pathway by mediating cleavage of Notch, generating the membrane-associated intermediate fragment called Notch extracellular truncation (NEXT). Plays a role in the proteolytic processing of ACE2. Plays a role in hemostasis through shedding of GP1BA, the platelet glycoprotein Ib alpha chain. Mediates the proteolytic cleavage of LAG3, leading to release the secreted form of LAG3. Mediates the proteolytic cleavage of IL6R, leading to the release of secreted form of IL6R. Mediates the proteolytic cleavage and shedding of FCGR3A upon NK cell stimulation, a mechanism that allows for increased NK cell motility and detachment from opsonized target cells. Cleaves TREM2, resulting in shedding of the TREM2 ectodomain. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 17Adam 17Snake Venom-Like ProteaseTnf-Alpha ConvertaseTnf-Alpha-Converting EnzymeCd Antigen Cd156b |
| Database Links | Reactome: R-HSA-1251985Reactome: R-HSA-1442490Reactome: R-HSA-177929Reactome: R-HSA-193692Reactome: R-HSA-2122948Reactome: R-HSA-2644606Reactome: R-HSA-2660826Reactome: R-HSA-2691232Reactome: R-HSA-2894862Reactome: R-HSA-5362798Reactome: R-HSA-75893Reactome: R-HSA-9662834Reactome: R-HSA-982772 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 17 antibodyAnti-Adam 17 antibodyAnti-Snake Venom-Like Protease antibodyAnti-Tnf-Alpha Convertase antibodyAnti-Tnf-Alpha-Converting Enzyme antibodyAnti-Cd Antigen Cd156b antibodyAnti-ADAM17 antibodyAnti-CSVP antibodyAnti-TACE antibody |
Information sourced from Uniprot.org
