Host: | Rabbit |
Applications: | WB/IHC-P/IF/ICC/ELISA |
Reactivity: | Human/Mouse/Rat |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
Purification: | Affinity purification |
Concentration: | Lot specific |
Dilution Range: | WB:1:500-1:2000IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | ADAM12 |
Gene ID: | 8038 |
Uniprot ID: | ADA12_HUMAN |
Immunogen Region: | 589-738 |
Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 589-738 of human ADAM12 (NP_067673.2). |
Immunogen Sequence: | ASRPVIGTNAVSIETNIPLQ QGGRILCRGTHVYLGDDMPD PGLVLAGTKCADGKICLNRQ CQNISVFGVHECAMQCHGRG VCNNRKNCHCEAHWAPPFCD KFGFGGSTDSGPIRQAEARQ EAAESNRERGQGQEPVGSQE HASTASLTLI |
Tissue Specificity | Isoform 1 is expressed in placenta and skeletal, cardiac, and smooth muscle. Isoform 2 seems to be expressed only in placenta or in embryo and fetus. Both forms were expressed in some tumor cells lines. Not detected in brain, lung, liver, kidney or pancreas. |
Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
Function | Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors. |
Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 12Adam 12Meltrin-Alpha |
Database Links | Reactome: R-HSA-177929Reactome: R-HSA-8941237 |
Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: SecretedIsoform 3: SecretedIsoform 4: Secreted |
Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 12 antibodyAnti-Adam 12 antibodyAnti-Meltrin-Alpha antibodyAnti-ADAM12 antibodyAnti-MLTN antibodyAnti-UNQ346 antibodyAnti-PRO545 antibody |
Information sourced from Uniprot.org