| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human/Mouse/Rat/Pig/Cow |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-ADAM12 (225-239) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 100kDa band observed in Human Heart lysates and approx 90+60kDa bands observed in Mouse, Rat and Pig Heart lysates (calculated MW of 99.5kDa according to NP_003465.3 and of 80. |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | ADAM12 |
| Gene ID: | 8038 |
| Uniprot ID: | ADA12_HUMAN |
| Immunogen Region: | 225-239 |
| Accession Number: | NP_003465.3; NP_067673.2 |
| Specificity: | This antibody is expected to recognize both reported isoforms (NP_003465.3; NP_067673.2). |
| Immunogen Sequence: | REFQRQGKDLEKVKQ |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 12Adam 12Meltrin-Alpha |
| Database Links | Reactome: R-HSA-177929Reactome: R-HSA-8941237 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: SecretedIsoform 3: SecretedIsoform 4: Secreted |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 12 antibodyAnti-Adam 12 antibodyAnti-Meltrin-Alpha antibodyAnti-ADAM12 antibodyAnti-MLTN antibodyAnti-UNQ346 antibodyAnti-PRO545 antibody |
Information sourced from Uniprot.org