Host: | Rabbit |
Applications: | WB |
Reactivity: | Human/Mouse |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description : | Rabbit polyclonal antibody anti-Disintegrin and metalloproteinase domain-containing protein 11 (600-650 aa) is suitable for use in Western Blot research applications. |
Clonality : | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Concentration: | 1 mg/mL |
Dilution Range: | WB 1:500-2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | ADAM11 |
Gene ID: | 4185 |
Uniprot ID: | ADA11_HUMAN |
Immunogen Region: | 600-650 aa |
Specificity: | This antibody detects endogenous levels of ADA11 at Human/Mouse |
Immunogen: | Synthesized peptide derived from the human ADA11 at the amino acid range 600-650 |
Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
Function | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress. Plays a role in spatial learning and motor coordination. Involved in the nociceptive pain response to chemical-derived stimulation. |
Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 11 Adam 11 Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein Mdc |
Database Links | Reactome: R-HSA-5682910 |
Cellular Localisation | Presynaptic Cell Membrane Single-Pass Type I Membrane Protein Perikaryon Cell Projection Axon Localizes To Basket Cell Terminals And Pinceaux |
Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 11 antibody Anti-Adam 11 antibody Anti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein antibody Anti-Mdc antibody Anti-ADAM11 antibody Anti-MDC antibody |
Information sourced from Uniprot.org