| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | ACTN1 |
| Gene ID: | 87 |
| Uniprot ID: | ACTN1_HUMAN |
| Immunogen Region: | 281-380 aa |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 281-380 of human Alpha-Actinin (NP_001093.1). |
| Immunogen Sequence: | KLASDLLEWIRRTIPWLENR VPENTMHAMQQKLEDFRDYR RLHKPPKVQEKCQLEINFNT LQTKLRLSNRPAFMPSEGRM VSDINNAWGCLEQVEKGYEE |
| Function | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. Association with IGSF8 regulates the immune synapse formation and is required for efficient T-cell activation. |
| Protein Name | Alpha-Actinin-1Alpha-Actinin Cytoskeletal IsoformF-Actin Cross-Linking ProteinNon-Muscle Alpha-Actinin-1 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-3000170Reactome: R-HSA-373753Reactome: R-HSA-446388Reactome: R-HSA-9013405Reactome: R-HSA-9013418Reactome: R-HSA-9035034 |
| Cellular Localisation | CytoplasmCytoskeletonMyofibrilSarcomereZ LineCell MembraneCell JunctionCell ProjectionRuffleColocalizes With Myoz2 And Ppp3ca At The Z-Line Of Heart And Skeletal MuscleColocalizes With Psd In Membrane Ruffles And Central Reticular Structures |
| Alternative Antibody Names | Anti-Alpha-Actinin-1 antibodyAnti-Alpha-Actinin Cytoskeletal Isoform antibodyAnti-F-Actin Cross-Linking Protein antibodyAnti-Non-Muscle Alpha-Actinin-1 antibodyAnti-ACTN1 antibody |
Information sourced from Uniprot.org
