| Short Description : | Rabbit polyclonal Actin-Cytoplasmic 1 (Met1-Phe375) antibody for use in ELISA, IHC and WB in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | ELISA/IHC/WB |
| Host: | Rabbit |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Purification: | Purified by antigen affinity column |
| Formulation: | 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. |
| Storage Instruction: | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
| Gene Symbol: | ACTB |
| Gene ID: | 60 |
| Uniprot ID: | ACTB_HUMAN |
| Immunogen: | E coli-derived recombinant Human Beta-actin (Met1-Phe375) |
| Immunogen Region: | Met1-Phe375 |
| Function | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. |
| Protein Name | Actin - Cytoplasmic 1Beta-Actin Cleaved Into - Actin - Cytoplasmic 1 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-190873Reactome: R-HSA-196025Reactome: R-HSA-2029482Reactome: R-HSA-3214847Reactome: R-HSA-389957Reactome: R-HSA-390450Reactome: R-HSA-3928662Reactome: R-HSA-3928665Reactome: R-HSA-418990Reactome: R-HSA-437239Reactome: R-HSA-4420097Reactome: R-HSA-445095Reactome: R-HSA-446353Reactome: R-HSA-5250924Reactome: R-HSA-5626467Reactome: R-HSA-5663213Reactome: R-HSA-5663220Reactome: R-HSA-5674135Reactome: R-HSA-5689603Reactome: R-HSA-5696394Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-8856828Reactome: R-HSA-9035034Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9662360Reactome: R-HSA-9662361Reactome: R-HSA-9664422Reactome: R-HSA-9824585Reactome: R-HSA-983231Reactome: R-HSA-9845323Reactome: R-HSA-9913351 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusLocalized In Cytoplasmic Mrnp Granules Containing Untranslated Mrnas |
| Alternative Antibody Names | Anti-Actin - Cytoplasmic 1 antibodyAnti-Beta-Actin Cleaved Into - Actin - Cytoplasmic 1 - N-Terminally Processed antibodyAnti-ACTB antibody |
Information sourced from Uniprot.org
![Anti-ACTB/Beta-actin/Beta Actin nanobody [SAA1234] (STJN000239)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/600x533/products/200852/413034/STJN000239-SDS-PAGE-1__31532.1749232548.jpg?c=1 "Anti-ACTB/Beta-actin/Beta Actin nanobody [SAA1234] (STJN000239)")
