![Anti-ACTB/Beta-actin/Beta Actin nanobody [SAA1234] (STJN000239)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/200852/413034/STJN000239-SDS-PAGE-1__31532.1749232548.jpg?c=1 "Anti-ACTB/Beta-actin/Beta Actin nanobody [SAA1234] (STJN000239)")
![Anti-ACTB/Beta-actin/Beta Actin nanobody [SAA1234] (STJN000239)](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/1280x1280/products/200852/413034/STJN000239-SDS-PAGE-1__31532.1749232548.jpg?c=1 "Anti-ACTB/Beta-actin/Beta Actin nanobody [SAA1234] (STJN000239)")
Anti-ACTB/Beta-actin/Beta Actin nanobody [SAA1234] (STJN000239)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-8His-Cys-tag
General Information
| Short Description | Alpaca monoclonal nanobody anti-Actin-Cytoplasmic 1 is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Applications | ELISA/IP/WB |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1234 |
| Isotype | VHH-8His-Cys-tag |
| Conjugation | Unconjugated |
| Concentration | 0.3 mg/mL |
| Purification | Purified by Nickel column. |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze-thaw cycles. Store at 4°C short term (1-2 weeks). Store at-20°C 12 months. Store at-80°C long term. |
Target Information
| Gene Symbol | ACTB |
| Gene ID | 60 |
| Uniprot ID | ACTB_HUMAN |
Additional Info
| Function | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. |
| Protein Name | Actin - Cytoplasmic 1Beta-Actin Cleaved Into - Actin - Cytoplasmic 1 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-190873Reactome: R-HSA-196025Reactome: R-HSA-2029482Reactome: R-HSA-3214847Reactome: R-HSA-389957Reactome: R-HSA-390450Reactome: R-HSA-3928662Reactome: R-HSA-3928665Reactome: R-HSA-418990Reactome: R-HSA-437239Reactome: R-HSA-4420097Reactome: R-HSA-445095Reactome: R-HSA-446353Reactome: R-HSA-5250924Reactome: R-HSA-5626467Reactome: R-HSA-5663213Reactome: R-HSA-5663220Reactome: R-HSA-5674135Reactome: R-HSA-5689603Reactome: R-HSA-5696394Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-8856828Reactome: R-HSA-9035034Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9662360Reactome: R-HSA-9662361Reactome: R-HSA-9664422Reactome: R-HSA-9824585Reactome: R-HSA-983231Reactome: R-HSA-9845323Reactome: R-HSA-9913351 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusLocalized In Cytoplasmic Mrnp Granules Containing Untranslated Mrnas |
| Alternative Nanobody Names | Anti-Actin - Cytoplasmic 1 nanobodyAnti-Beta-Actin Cleaved Into - Actin - Cytoplasmic 1 - N-Terminally Processed nanobodyAnti-ACTB nanobody |
Information sourced from Uniprot.org