| Function | Bifunctional iron sensor that switches between 2 activities depending on iron availability. Iron deprivation, promotes its mRNA binding activity through which it regulates the expression of genes involved in iron uptake, sequestration and utilization. Binds to iron-responsive elements (IRES) in the untranslated region of target mRNAs preventing for instance the translation of ferritin and aminolevulinic acid synthase and stabilizing the transferrin receptor mRNA. Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate. |
| Protein Name | Cytoplasmic Aconitate HydrataseAconitaseCitrate Hydro-LyaseFerritin Repressor ProteinIron Regulatory Protein 1Irp1Iron-Responsive Element-Binding Protein 1Ire-Bp 1 |
| Database Links | Reactome: R-HSA-389542Reactome: R-HSA-917937 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Antibody Names | Anti-Cytoplasmic Aconitate Hydratase antibodyAnti-Aconitase antibodyAnti-Citrate Hydro-Lyase antibodyAnti-Ferritin Repressor Protein antibodyAnti-Iron Regulatory Protein 1 antibodyAnti-Irp1 antibodyAnti-Iron-Responsive Element-Binding Protein 1 antibodyAnti-Ire-Bp 1 antibodyAnti-ACO1 antibodyAnti-IREB1 antibody |
Information sourced from Uniprot.org
