• Immunofluorescence analysis of MCF7 cells, using CCRL1 Antibody. The picture on the right is blocked with the synthesized peptide.
  • Western blot analysis of lysates from HepG2 cells, using CCRL1 Antibody. The lane on the right is blocked with the synthesized peptide.
  • Western blot analysis of various cells using CCRL1 Polyclonal Antibody

Anti-ACKR4 antibody (291-340 aa) (STJ92078)

SKU:
STJ92078

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IF/ELISA
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Atypical chemokine receptor 4 (291-340 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:40000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACKR4
Gene ID: 51554
Uniprot ID: ACKR4_HUMAN
Immunogen Region: 291-340 aa
Specificity: CCRL1 Polyclonal Antibody detects endogenous levels of CCRL1 protein.
Immunogen: The antiserum was produced against synthesized peptide derived from the human CCRL1 at the amino acid range 291-340
Post Translational Modifications The Ser/Thr residues in the C-terminal cytoplasmic tail may be phosphorylated.
Function Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
Protein Name Atypical Chemokine Receptor 4
C-C Chemokine Receptor Type 11
C-C Ckr-11
Cc-Ckr-11
Ccr-11
Cc Chemokine Receptor-Like 1
Ccrl1
Ccx Ckr
Database Links Reactome: R-HSA-380108
Cellular Localisation Early Endosome
Recycling Endosome
Cell Membrane
Multi-Pass Membrane Protein
Predominantly Localizes To Endocytic Vesicles
And Upon Stimulation By The Ligand Is Internalized Via Caveolae
Once Internalized
The Ligand Dissociates From The Receptor
And Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane
Alternative Antibody Names Anti-Atypical Chemokine Receptor 4 antibody
Anti-C-C Chemokine Receptor Type 11 antibody
Anti-C-C Ckr-11 antibody
Anti-Cc-Ckr-11 antibody
Anti-Ccr-11 antibody
Anti-Cc Chemokine Receptor-Like 1 antibody
Anti-Ccrl1 antibody
Anti-Ccx Ckr antibody
Anti-ACKR4 antibody
Anti-CCBP2 antibody
Anti-CCR11 antibody
Anti-CCRL1 antibody
Anti-VSHK1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance