Anti-ACKR1/CD234 nanobody [SAA2301] (STJN000684)
SPECIFICATIONS
ClonalityMonoclonal
HostAlpaca
ConjugationUnconjugated
IsotypeVHH-His
General Information
| Short Description | Alpaca monoclonal nanobody anti-ACKR1/CD234 is suitable for use in ELISA, Western Blot, Immunoprecipitation and FConfocal Microscopy research applications. |
| Applications | ELISA/WB/IP/FCM |
| Host | Alpaca |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA2301 |
| Isotype | VHH-His |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Purified by Nickel column. |
| Dilution Range | ELISA: 1:2000-1:20000; WB: 1:500-1:2000 |
| Formulation | 0.01M PBS pH 7.4 |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Endotoxin | Please contact with the lab for this information. |
Target Information
| Gene Symbol | ACKR1 |
| Gene ID | 2532 |
| Uniprot ID | ACKR1_HUMAN |
Additional Info
| Post Translational Modifications | Sulfation at Tyr-41 facilitates interaction with MGSA/CXCL1, RANTES/CCL5 and MCP-1/CCL2 but not IL8/CXCL8. Sulfation at Tyr-30 facilitates interaction with IL8/CXCL8. (Microbial infection) Sulfation at Tyr-41 facilitates interaction with Plasmodium vivax Duffy receptor (PVDR). Sulfation at Tyr-30/Tyr-41 and Tyr-41 alone increases binding affinity of Plasmodium vivax parasites and likely promotes invasion of red blood cells. (Microbial infection) Sulfation at Tyr-41 facilitates interaction with Plasmodium knowlesi Duffy receptor alpha form (DBPalpha). Sulfation at Tyr-30/Tyr-41 and Tyr-41 alone increases binding affinity of Plasmodium knowlesi parasites and likely promotes invasion of red blood cells. |
| Function | Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes.when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. (Microbial infection) Acts as a receptor for the malaria parasite Plasmodium vivax. (Microbial infection) Acts as a receptor for the malaria parasite Plasmodium knowlesi. |
| Protein Name | Atypical Chemokine Receptor 1Duffy Antigen Receptor For ChemokinesDuffy Antigen/Chemokine ReceptorDuffy Blood Group AntigenFy GlycoproteinGpfyGlycoprotein DPlasmodium Vivax ReceptorCd Antigen Cd234 |
| Database Links | Reactome: R-HSA-375276 |
| Cellular Localisation | Early EndosomeRecycling EndosomeMembraneMulti-Pass Membrane ProteinPredominantly Localizes To Endocytic VesiclesAnd Upon Stimulation By The Ligand Is Internalized Via CaveolaeOnce InternalizedThe Ligand Dissociates From The ReceptorAnd Is Targeted To Degradation While The Receptor Is Recycled Back To The Cell Membrane |
| Alternative Nanobody Names | Anti-Atypical Chemokine Receptor 1 nanobodyAnti-Duffy Antigen Receptor For Chemokines nanobodyAnti-Duffy Antigen/Chemokine Receptor nanobodyAnti-Duffy Blood Group Antigen nanobodyAnti-Fy Glycoprotein nanobodyAnti-Gpfy nanobodyAnti-Glycoprotein D nanobodyAnti-Plasmodium Vivax Receptor nanobodyAnti-Cd Antigen Cd234 nanobodyAnti-ACKR1 nanobodyAnti-DARC nanobodyAnti-FY nanobodyAnti-GPD nanobody |
Information sourced from Uniprot.org